FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022148652> ?p ?o ?g. }

• W2022148652 endingPage "306" @default.
• W2022148652 startingPage "299" @default.
• W2022148652 abstract "Recent studies indicate that 5-HT1A receptor agonists stimulate noradrenaline release in the brain. Here we investigate the mechanism underlying the increase in extracellular noradrenaline induced by (+/-)-MDL 73005EF, a weak 5-HT1A receptor agonist. Extracellular noradrenaline was measured in the hippocampus of the awake rat using microdialysis. (+/-)-MDL 73005EF (0.1, 1 and 5 mg/kg s.c.) caused a dose-related increase in noradrenaline. The active S(-)- enantiomer of MDL 73005EF (1 mg/kg s.c.) also increased noradrenaline whereas the inactive R(+)- enantiomer (1 mg/kg s.c.) did not. Measurements of extracellular 5-HT in hippocampus of anaesthetised rats confirmed that the 5-HT1A receptor agonist action of (+/-)-MDL 73005EF resides in the S(-)- enantiomer. Thus, S(-)-MDL 73005EF (0.3 and 1 mg/kg s.c.) markedly decreased 5-HT, whereas R(+)-MDL 73005EF (1 mg/kg s.c.) did not. The noradrenaline response to (+/-)-MDL 73005EF (1 mg/kg s.c.) was significantly blocked by the selective 5-T1A receptor antagonist, WAY 100635 (1 but not 0.3 mg/kg s.c). The noradrenaline response to (+/-)-MDL 73005EF (1 mg/kg s.c.) was not modified by pretreatment with the 5-HT synthesis inhibitor p-chlorophenylalanine. Intra-hippocampal application of (+/-)-MDL 73005EF (10 microM in perfusion medium) did not increase noradrenaline. Although (+/-)-MDL 73005EF has moderate affinity for dopamine D2 binding sites, the dopamine D2 receptor antagonist, remoxipride (1 mg/kg s.c.) did not increase noradrenaline. In conclusion, our data suggest that (+/-)-MDL 73005EF increases noradrenaline release in rat hippocampus through activation of 5HT1A receptors that appear to be located postsynaptically. These data are discussed in relation to the antidepressant/anxiolytic effects of 5-HT1A agonists." @default.
• W2022148652 created "2016-06-24" @default.
• W2022148652 creator A5000580656 @default.
• W2022148652 creator A5012496186 @default.
• W2022148652 creator A5016717006 @default.
• W2022148652 date "1999-02-01" @default.
• W2022148652 modified "2023-10-18" @default.
• W2022148652 title "Influence of 5-HT1A receptors on central noradrenergic activity: microdialysis studies using (±)-MDL 73005EF and its enantiomers" @default.
• W2022148652 cites W107475310 @default.
• W2022148652 cites W1963690073 @default.
• W2022148652 cites W1964291278 @default.
• W2022148652 cites W1971929330 @default.
• W2022148652 cites W1974554583 @default.
• W2022148652 cites W1975487675 @default.
• W2022148652 cites W1979121767 @default.
• W2022148652 cites W1981485683 @default.
• W2022148652 cites W1988297901 @default.
• W2022148652 cites W1988411278 @default.
• W2022148652 cites W1995461188 @default.
• W2022148652 cites W1999490123 @default.
• W2022148652 cites W2015374273 @default.
• W2022148652 cites W2025505082 @default.
• W2022148652 cites W2058556858 @default.
• W2022148652 cites W2065320993 @default.
• W2022148652 cites W2065664987 @default.
• W2022148652 cites W2084215923 @default.
• W2022148652 cites W2088537907 @default.
• W2022148652 cites W2093548650 @default.
• W2022148652 cites W2130835333 @default.
• W2022148652 cites W2179282691 @default.
• W2022148652 doi "https://doi.org/10.1016/s0028-3908(98)00175-0" @default.
• W2022148652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10218872" @default.
• W2022148652 hasPublicationYear "1999" @default.
• W2022148652 type Work @default.
• W2022148652 sameAs 2022148652 @default.
• W2022148652 citedByCount "48" @default.
• W2022148652 countsByYear W20221486522012 @default.
• W2022148652 countsByYear W20221486522013 @default.
• W2022148652 countsByYear W20221486522014 @default.
• W2022148652 countsByYear W20221486522015 @default.
• W2022148652 countsByYear W20221486522016 @default.
• W2022148652 countsByYear W20221486522017 @default.
• W2022148652 countsByYear W20221486522020 @default.
• W2022148652 countsByYear W20221486522021 @default.
• W2022148652 countsByYear W20221486522023 @default.
• W2022148652 crossrefType "journal-article" @default.
• W2022148652 hasAuthorship W2022148652A5000580656 @default.
• W2022148652 hasAuthorship W2022148652A5012496186 @default.
• W2022148652 hasAuthorship W2022148652A5016717006 @default.
• W2022148652 hasConcept C126322002 @default.
• W2022148652 hasConcept C134018914 @default.
• W2022148652 hasConcept C170493617 @default.
• W2022148652 hasConcept C185592680 @default.
• W2022148652 hasConcept C2775864247 @default.
• W2022148652 hasConcept C2776885963 @default.
• W2022148652 hasConcept C2778122271 @default.
• W2022148652 hasConcept C2778938600 @default.
• W2022148652 hasConcept C2781093953 @default.
• W2022148652 hasConcept C28406088 @default.
• W2022148652 hasConcept C50156730 @default.
• W2022148652 hasConcept C513476851 @default.
• W2022148652 hasConcept C53910766 @default.
• W2022148652 hasConcept C55493867 @default.
• W2022148652 hasConcept C71924100 @default.
• W2022148652 hasConcept C86803240 @default.
• W2022148652 hasConcept C98274493 @default.
• W2022148652 hasConceptScore W2022148652C126322002 @default.
• W2022148652 hasConceptScore W2022148652C134018914 @default.
• W2022148652 hasConceptScore W2022148652C170493617 @default.
• W2022148652 hasConceptScore W2022148652C185592680 @default.
• W2022148652 hasConceptScore W2022148652C2775864247 @default.
• W2022148652 hasConceptScore W2022148652C2776885963 @default.
• W2022148652 hasConceptScore W2022148652C2778122271 @default.
• W2022148652 hasConceptScore W2022148652C2778938600 @default.
• W2022148652 hasConceptScore W2022148652C2781093953 @default.
• W2022148652 hasConceptScore W2022148652C28406088 @default.
• W2022148652 hasConceptScore W2022148652C50156730 @default.
• W2022148652 hasConceptScore W2022148652C513476851 @default.
• W2022148652 hasConceptScore W2022148652C53910766 @default.
• W2022148652 hasConceptScore W2022148652C55493867 @default.
• W2022148652 hasConceptScore W2022148652C71924100 @default.
• W2022148652 hasConceptScore W2022148652C86803240 @default.
• W2022148652 hasConceptScore W2022148652C98274493 @default.
• W2022148652 hasIssue "2" @default.
• W2022148652 hasLocation W20221486521 @default.
• W2022148652 hasLocation W20221486522 @default.
• W2022148652 hasOpenAccess W2022148652 @default.
• W2022148652 hasPrimaryLocation W20221486521 @default.
• W2022148652 hasRelatedWork W1491233801 @default.
• W2022148652 hasRelatedWork W2013349831 @default.
• W2022148652 hasRelatedWork W2013688328 @default.
• W2022148652 hasRelatedWork W2026307269 @default.
• W2022148652 hasRelatedWork W2031521356 @default.
• W2022148652 hasRelatedWork W2036081896 @default.
• W2022148652 hasRelatedWork W2063368926 @default.
• W2022148652 hasRelatedWork W2071873589 @default.
• W2022148652 hasRelatedWork W2991822442 @default.
• W2022148652 hasRelatedWork W2008164755 @default.

• next