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- W2022148808 abstract "Nucleic acid damage by reactive nitrogen and oxygen species may contribute to the carcinogenesis associated with chronic infection and inflammation. We examined 8-nitroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) formation and nitric oxide (NO) production in hamsters infected with Opisthorchis viverrini (OV). Formation of 8-nitroguanine was assessed immunohistochemically with an antibody specific for 8-nitroguanine. 8-Nitroguanine formation was found mainly in the cytoplasm and slightly in the nucleus of inflammatory cells and epithelial lining of bile duct at inflammatory areas in the liver. 8-Nitroguanine immunoreactivity reached the highest intensity on day 30. A time profile of 8-nitroguanine formation was closely associated with that of plasma nitrate/nitrite. HPLC with an electrochemical detector revealed that the amount of 8-oxodG in the liver reached the maximal level on day 21. The mechanisms of 8-oxodG and 8-nitroguanine formation via O2− and NO production triggered by OV infection were discussed in relation to cholangiocarcinoma development." @default.
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- W2022148808 date "2003-09-01" @default.
- W2022148808 modified "2023-10-17" @default.
- W2022148808 title "8-Nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini" @default.
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- W2022148808 doi "https://doi.org/10.1016/j.bbrc.2003.08.039" @default.
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