FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022149566> ?p ?o ?g. }

• W2022149566 endingPage "1739" @default.
• W2022149566 startingPage "1739" @default.
• W2022149566 abstract "Nucleotide oligomerization domain-2 (NOD2) plays an important role in innate immunity to sense muramyl dipeptide (MDP), a component of bacterial cell walls. Notably, NOD2 is linked to eye inflammation because mutations in NOD2 cause a granulomatous type of uveitis called Blau syndrome. A mouse model of NOD2-dependent ocular inflammation was employed to test the role of a cytokine strongly implicated in granuloma formation, IFN-gamma, in order to gain insight into downstream functional consequences of NOD2 activation within the eye triggering uveitis.Mice deficient in IFN-gamma, NOD2, or CD11b and their wild-type controls were treated with intravitreal injection of MDP in the presence or absence of IFN-gamma. IFN-gamma production in the eye was measured by ELISA. The intravascular inflammatory response within the iris was quantified by intravital microscopy.NOD2 activation resulted in the production of IFN-gamma within the eye. Deficiency in IFN-gamma diminished the development of MDP-induced uveitis, indicating its crucial role in downstream inflammatory events triggered by NOD2. Moreover, exogenous IFN-gamma markedly exacerbated MDP-induced ocular inflammation in a NOD2-dependent mechanism. The potential of IFN-gamma to enhance inflammation required the adhesion molecule CD11b because CD11b-deficient mice failed to show the synergistic effects of IFN-gamma and MDP cotreatment on adhering and infiltrating cells.IFN-gamma was identified as a downstream mediator of NOD2-driven inflammation and the capacity of IFN-gamma in vivo to enhance the inflammatory potential of NOD2 was demonstrated. Extrapolation of these findings in mice suggests that the dysregulation of IFN-gamma may occur in patients with Blau syndrome, thereby contributing to the granulomatous nature of the disease." @default.
• W2022149566 created "2016-06-24" @default.
• W2022149566 creator A5001048129 @default.
• W2022149566 creator A5010962261 @default.
• W2022149566 creator A5022573562 @default.
• W2022149566 creator A5033719825 @default.
• W2022149566 creator A5052070298 @default.
• W2022149566 date "2009-04-01" @default.
• W2022149566 modified "2023-09-24" @default.
• W2022149566 title "Nucleotide Oligomerization Domain-2 (NOD2)-Induced Uveitis: Dependence on IFN-γ" @default.
• W2022149566 cites W1514704168 @default.
• W2022149566 cites W1542410645 @default.
• W2022149566 cites W1642457845 @default.
• W2022149566 cites W1670573097 @default.
• W2022149566 cites W1768580582 @default.
• W2022149566 cites W1824910897 @default.
• W2022149566 cites W1971916873 @default.
• W2022149566 cites W1974366841 @default.
• W2022149566 cites W1978335738 @default.
• W2022149566 cites W1982476665 @default.
• W2022149566 cites W1988232165 @default.
• W2022149566 cites W1996610549 @default.
• W2022149566 cites W2000447021 @default.
• W2022149566 cites W2015011627 @default.
• W2022149566 cites W2018542503 @default.
• W2022149566 cites W2020125849 @default.
• W2022149566 cites W2037382237 @default.
• W2022149566 cites W2041170922 @default.
• W2022149566 cites W2044740124 @default.
• W2022149566 cites W2057610674 @default.
• W2022149566 cites W2058209145 @default.
• W2022149566 cites W2068353958 @default.
• W2022149566 cites W2072091233 @default.
• W2022149566 cites W2075583035 @default.
• W2022149566 cites W2085605790 @default.
• W2022149566 cites W2090279487 @default.
• W2022149566 cites W2095891614 @default.
• W2022149566 cites W2096443475 @default.
• W2022149566 cites W2104040734 @default.
• W2022149566 cites W2111900042 @default.
• W2022149566 cites W2115483836 @default.
• W2022149566 cites W2120247510 @default.
• W2022149566 cites W2125097883 @default.
• W2022149566 cites W2136736147 @default.
• W2022149566 cites W2140906887 @default.
• W2022149566 cites W2142257636 @default.
• W2022149566 cites W2143292302 @default.
• W2022149566 cites W2146860388 @default.
• W2022149566 cites W2148088316 @default.
• W2022149566 cites W2153130127 @default.
• W2022149566 cites W2153571844 @default.
• W2022149566 cites W2158974881 @default.
• W2022149566 cites W2165985213 @default.
• W2022149566 cites W2168232558 @default.
• W2022149566 cites W2169322130 @default.
• W2022149566 doi "https://doi.org/10.1167/iovs.08-2756" @default.
• W2022149566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3089593" @default.
• W2022149566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19098321" @default.
• W2022149566 hasPublicationYear "2009" @default.
• W2022149566 type Work @default.
• W2022149566 sameAs 2022149566 @default.
• W2022149566 citedByCount "35" @default.
• W2022149566 countsByYear W20221495662012 @default.
• W2022149566 countsByYear W20221495662013 @default.
• W2022149566 countsByYear W20221495662014 @default.
• W2022149566 countsByYear W20221495662015 @default.
• W2022149566 countsByYear W20221495662017 @default.
• W2022149566 countsByYear W20221495662018 @default.
• W2022149566 countsByYear W20221495662019 @default.
• W2022149566 countsByYear W20221495662020 @default.
• W2022149566 countsByYear W20221495662021 @default.
• W2022149566 countsByYear W20221495662022 @default.
• W2022149566 crossrefType "journal-article" @default.
• W2022149566 hasAuthorship W2022149566A5001048129 @default.
• W2022149566 hasAuthorship W2022149566A5010962261 @default.
• W2022149566 hasAuthorship W2022149566A5022573562 @default.
• W2022149566 hasAuthorship W2022149566A5033719825 @default.
• W2022149566 hasAuthorship W2022149566A5052070298 @default.
• W2022149566 hasBestOaLocation W20221495662 @default.
• W2022149566 hasConcept C136449434 @default.
• W2022149566 hasConcept C164027704 @default.
• W2022149566 hasConcept C203014093 @default.
• W2022149566 hasConcept C2776194053 @default.
• W2022149566 hasConcept C2776444769 @default.
• W2022149566 hasConcept C2776914184 @default.
• W2022149566 hasConcept C2778690821 @default.
• W2022149566 hasConcept C7573103 @default.
• W2022149566 hasConcept C86803240 @default.
• W2022149566 hasConcept C8891405 @default.
• W2022149566 hasConceptScore W2022149566C136449434 @default.
• W2022149566 hasConceptScore W2022149566C164027704 @default.
• W2022149566 hasConceptScore W2022149566C203014093 @default.
• W2022149566 hasConceptScore W2022149566C2776194053 @default.
• W2022149566 hasConceptScore W2022149566C2776444769 @default.
• W2022149566 hasConceptScore W2022149566C2776914184 @default.
• W2022149566 hasConceptScore W2022149566C2778690821 @default.
• W2022149566 hasConceptScore W2022149566C7573103 @default.
• W2022149566 hasConceptScore W2022149566C86803240 @default.

• next