FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022149910> ?p ?o ?g. }

• W2022149910 endingPage "e45378" @default.
• W2022149910 startingPage "e45378" @default.
• W2022149910 abstract "The up-regulation of CCAAT/enhancer binding protein delta (CEBPD) has frequently been observed in macrophages in age-associated disorders, including rheumatoid arthritis (RA). However, the role of macrophage CEBPD in the pathogenesis of RA is unclear.We found that the collagen-induced arthritis (CIA) score and the number of affected paws in Cebpd(-/-) mice were significantly decreased compared with the wild-type (WT) mice. The histological analysis revealed an attenuated CIA in Cebpd(-/-) mice, as shown by reduced pannus formation and greater integrity of joint architecture in affected paws of Cebpd(-/-) mice compared with WT mice. In addition, immunohistochemistry analysis revealed decreased pannus proliferation and angiogenesis in Cebpd(-/-) mice compared with WT mice. CEBPD activated in macrophages played a functional role in promoting the tube formation of endothelial cells and the migration and proliferation of synoviocytes. In vivo DNA binding assays and reporter assays showed that CEBPD up-regulated CCL20, CXCL1, IL23A and TNFAIP6 transcripts through direct binding to their promoter regions. CCL20, IL23A, CXCL1 and TNFAIP6 contributed to the migration and proliferation of synoviocytes, and the latter two proteins were involved in tube formation of endothelial cells. Finally, two anti-inflammatory chemicals, inotilone and rosmanol, reduced the expression of CEBPD and its downstream targets and mitigated the above phenomena.Collectively, our findings suggest that CEBPD and its downstream effectors could be biomarkers for the diagnosis of RA and potentially serve as therapeutic targets for RA therapy." @default.
• W2022149910 created "2016-06-24" @default.
• W2022149910 creator A5000832958 @default.
• W2022149910 creator A5011400509 @default.
• W2022149910 creator A5013196995 @default.
• W2022149910 creator A5020273179 @default.
• W2022149910 creator A5026397905 @default.
• W2022149910 creator A5037149440 @default.
• W2022149910 creator A5042681614 @default.
• W2022149910 creator A5090039930 @default.
• W2022149910 date "2012-09-24" @default.
• W2022149910 modified "2023-10-18" @default.
• W2022149910 title "Role of Macrophage CCAAT/Enhancer Binding Protein Delta in the Pathogenesis of Rheumatoid Arthritis in Collagen-Induced Arthritic Mice" @default.
• W2022149910 cites W1499501743 @default.
• W2022149910 cites W1523595999 @default.
• W2022149910 cites W1569650715 @default.
• W2022149910 cites W1677487429 @default.
• W2022149910 cites W1873126901 @default.
• W2022149910 cites W1966999437 @default.
• W2022149910 cites W1968375296 @default.
• W2022149910 cites W1971708477 @default.
• W2022149910 cites W1973208496 @default.
• W2022149910 cites W1980233065 @default.
• W2022149910 cites W1980671882 @default.
• W2022149910 cites W1983247385 @default.
• W2022149910 cites W1988054872 @default.
• W2022149910 cites W1996921732 @default.
• W2022149910 cites W2006122359 @default.
• W2022149910 cites W2009887653 @default.
• W2022149910 cites W2015358846 @default.
• W2022149910 cites W2020971579 @default.
• W2022149910 cites W2023128342 @default.
• W2022149910 cites W2025144955 @default.
• W2022149910 cites W2026818910 @default.
• W2022149910 cites W2026865649 @default.
• W2022149910 cites W2036584139 @default.
• W2022149910 cites W2036806110 @default.
• W2022149910 cites W2054049887 @default.
• W2022149910 cites W2062291196 @default.
• W2022149910 cites W2063432508 @default.
• W2022149910 cites W2069548932 @default.
• W2022149910 cites W2070871300 @default.
• W2022149910 cites W2073298562 @default.
• W2022149910 cites W2081829590 @default.
• W2022149910 cites W2083043675 @default.
• W2022149910 cites W2086350485 @default.
• W2022149910 cites W2086889757 @default.
• W2022149910 cites W2091360431 @default.
• W2022149910 cites W2092704138 @default.
• W2022149910 cites W2096216039 @default.
• W2022149910 cites W2114027214 @default.
• W2022149910 cites W2116059341 @default.
• W2022149910 cites W2116828514 @default.
• W2022149910 cites W2120312541 @default.
• W2022149910 cites W2121784455 @default.
• W2022149910 cites W2121874550 @default.
• W2022149910 cites W2123333870 @default.
• W2022149910 cites W2123922653 @default.
• W2022149910 cites W2130140108 @default.
• W2022149910 cites W2133692536 @default.
• W2022149910 cites W2139519365 @default.
• W2022149910 cites W2142184778 @default.
• W2022149910 cites W2151729918 @default.
• W2022149910 cites W2151754338 @default.
• W2022149910 cites W2154504271 @default.
• W2022149910 cites W2159833922 @default.
• W2022149910 cites W2164556451 @default.
• W2022149910 cites W2189172124 @default.
• W2022149910 doi "https://doi.org/10.1371/journal.pone.0045378" @default.
• W2022149910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3454428" @default.
• W2022149910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23028973" @default.
• W2022149910 hasPublicationYear "2012" @default.
• W2022149910 type Work @default.
• W2022149910 sameAs 2022149910 @default.
• W2022149910 citedByCount "48" @default.
• W2022149910 countsByYear W20221499102013 @default.
• W2022149910 countsByYear W20221499102014 @default.
• W2022149910 countsByYear W20221499102015 @default.
• W2022149910 countsByYear W20221499102017 @default.
• W2022149910 countsByYear W20221499102018 @default.
• W2022149910 countsByYear W20221499102019 @default.
• W2022149910 countsByYear W20221499102021 @default.
• W2022149910 countsByYear W20221499102022 @default.
• W2022149910 countsByYear W20221499102023 @default.
• W2022149910 crossrefType "journal-article" @default.
• W2022149910 hasAuthorship W2022149910A5000832958 @default.
• W2022149910 hasAuthorship W2022149910A5011400509 @default.
• W2022149910 hasAuthorship W2022149910A5013196995 @default.
• W2022149910 hasAuthorship W2022149910A5020273179 @default.
• W2022149910 hasAuthorship W2022149910A5026397905 @default.
• W2022149910 hasAuthorship W2022149910A5037149440 @default.
• W2022149910 hasAuthorship W2022149910A5042681614 @default.
• W2022149910 hasAuthorship W2022149910A5090039930 @default.
• W2022149910 hasBestOaLocation W20221499101 @default.
• W2022149910 hasConcept C13373296 @default.
• W2022149910 hasConcept C153911025 @default.
• W2022149910 hasConcept C185592680 @default.
• W2022149910 hasConcept C203014093 @default.

• next