Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022149954> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2022149954 endingPage "954" @default.
- W2022149954 startingPage "946" @default.
- W2022149954 abstract "We previously demonstrated that CD8(+)/TCR(-) bone marrow cells facilitate engraftment of HSC in allogeneic recipients without causing graft-vs-host disease. Whether facilitating cells (FC) develop from T cells or represent a distinct lineage has not been determined.In the present studies, we characterized the lineage derivation of FC, defined the role for the CD3 complex in allogeneic facilitation, and demonstrated syngeneic facilitation by FC but not T cells.We demonstrate for the first time that FC development and function is independent of T cells and cannot be replaced by them. Purified GFP(+) HSC transplanted in syngeneic recipients produce GFP(+) FC, which facilitate in secondary transplants, confirming that FC are derived from HSC. In addition, FC, but not T cells, potently facilitate the engraftment of suboptimal numbers of HSC in syngeneic recipients. Notably, FC contain the transcripts for CD3 epsilon and CD3 delta, but not TCR alpha or TCR beta, excluding the possibility of T-cell contamination. Genetic mutations that generate a functional deficiency in CD3 signaling significantly impair FC function in allogeneic facilitation (p=0.006).Taken together, these data clearly distinguish FC from T cells. Moreover, they indicate that FC require the CD3 epsilon gene to facilitate allogeneic HSC engraftment. The unique function(s) of FC make them an attractive focus for new cell-based therapeutic approaches to enhance HSC engraftment while reducing toxicity, especially when limiting numbers of HSC are available." @default.
- W2022149954 created "2016-06-24" @default.
- W2022149954 creator A5015841202 @default.
- W2022149954 creator A5039214863 @default.
- W2022149954 creator A5050419480 @default.
- W2022149954 creator A5060383525 @default.
- W2022149954 creator A5061655023 @default.
- W2022149954 creator A5067293999 @default.
- W2022149954 creator A5082588138 @default.
- W2022149954 date "2004-10-01" @default.
- W2022149954 modified "2023-09-26" @default.
- W2022149954 title "Graft facilitating cells are derived from hematopoietic stem cells and functionally require CD3, but are distinct from T lymphocytes" @default.
- W2022149954 cites W1581464052 @default.
- W2022149954 cites W1595037199 @default.
- W2022149954 cites W1599081529 @default.
- W2022149954 cites W2000156766 @default.
- W2022149954 cites W2005827339 @default.
- W2022149954 cites W2065055879 @default.
- W2022149954 cites W2077522103 @default.
- W2022149954 cites W2082603557 @default.
- W2022149954 cites W2083192413 @default.
- W2022149954 cites W2090831304 @default.
- W2022149954 cites W2137780359 @default.
- W2022149954 cites W2149326695 @default.
- W2022149954 cites W2151206902 @default.
- W2022149954 cites W2407688232 @default.
- W2022149954 cites W2411127532 @default.
- W2022149954 cites W4247957095 @default.
- W2022149954 cites W62199461 @default.
- W2022149954 doi "https://doi.org/10.1016/j.exphem.2004.07.011" @default.
- W2022149954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15504550" @default.
- W2022149954 hasPublicationYear "2004" @default.
- W2022149954 type Work @default.
- W2022149954 sameAs 2022149954 @default.
- W2022149954 citedByCount "38" @default.
- W2022149954 countsByYear W20221499542012 @default.
- W2022149954 countsByYear W20221499542014 @default.
- W2022149954 countsByYear W20221499542016 @default.
- W2022149954 countsByYear W20221499542017 @default.
- W2022149954 countsByYear W20221499542018 @default.
- W2022149954 countsByYear W20221499542019 @default.
- W2022149954 countsByYear W20221499542021 @default.
- W2022149954 crossrefType "journal-article" @default.
- W2022149954 hasAuthorship W2022149954A5015841202 @default.
- W2022149954 hasAuthorship W2022149954A5039214863 @default.
- W2022149954 hasAuthorship W2022149954A5050419480 @default.
- W2022149954 hasAuthorship W2022149954A5060383525 @default.
- W2022149954 hasAuthorship W2022149954A5061655023 @default.
- W2022149954 hasAuthorship W2022149954A5067293999 @default.
- W2022149954 hasAuthorship W2022149954A5082588138 @default.
- W2022149954 hasBestOaLocation W20221499541 @default.
- W2022149954 hasConcept C109159458 @default.
- W2022149954 hasConcept C114684123 @default.
- W2022149954 hasConcept C167672396 @default.
- W2022149954 hasConcept C19317047 @default.
- W2022149954 hasConcept C203014093 @default.
- W2022149954 hasConcept C2776090121 @default.
- W2022149954 hasConcept C2780007613 @default.
- W2022149954 hasConcept C28328180 @default.
- W2022149954 hasConcept C86803240 @default.
- W2022149954 hasConcept C8891405 @default.
- W2022149954 hasConcept C95444343 @default.
- W2022149954 hasConceptScore W2022149954C109159458 @default.
- W2022149954 hasConceptScore W2022149954C114684123 @default.
- W2022149954 hasConceptScore W2022149954C167672396 @default.
- W2022149954 hasConceptScore W2022149954C19317047 @default.
- W2022149954 hasConceptScore W2022149954C203014093 @default.
- W2022149954 hasConceptScore W2022149954C2776090121 @default.
- W2022149954 hasConceptScore W2022149954C2780007613 @default.
- W2022149954 hasConceptScore W2022149954C28328180 @default.
- W2022149954 hasConceptScore W2022149954C86803240 @default.
- W2022149954 hasConceptScore W2022149954C8891405 @default.
- W2022149954 hasConceptScore W2022149954C95444343 @default.
- W2022149954 hasIssue "10" @default.
- W2022149954 hasLocation W20221499541 @default.
- W2022149954 hasLocation W20221499542 @default.
- W2022149954 hasOpenAccess W2022149954 @default.
- W2022149954 hasPrimaryLocation W20221499541 @default.
- W2022149954 hasRelatedWork W138661586 @default.
- W2022149954 hasRelatedWork W1981563612 @default.
- W2022149954 hasRelatedWork W2003301929 @default.
- W2022149954 hasRelatedWork W2015860161 @default.
- W2022149954 hasRelatedWork W2059422010 @default.
- W2022149954 hasRelatedWork W2093020311 @default.
- W2022149954 hasRelatedWork W2108007089 @default.
- W2022149954 hasRelatedWork W2110363972 @default.
- W2022149954 hasRelatedWork W4306155276 @default.
- W2022149954 hasRelatedWork W72712021 @default.
- W2022149954 hasVolume "32" @default.
- W2022149954 isParatext "false" @default.
- W2022149954 isRetracted "false" @default.
- W2022149954 magId "2022149954" @default.
- W2022149954 workType "article" @default.