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• W2022151130 abstract "The synthesis and biological evaluation of stereoisomers in tubulysin D are described. The stereoselective synthesis of all possible stereoisomers of C-11 and C-13 positions in tubulysin D was achieved by employing 1'-epi-Tuv-Me, 3'-epi-Tuv-Me, and ent-Tuv-Me and their biological properties were evaluated. It is clear that the stereochemistries of the C-11 and C-13 positions in tubulysin D have no practical impact on the inhibition of tubulin polymerization but play a role in the potent antiproliferative activities." @default.
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• W2022151130 date "2011-01-01" @default.
• W2022151130 modified "2023-09-24" @default.
• W2022151130 title "Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline" @default.
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• W2022151130 doi "https://doi.org/10.1016/j.bmcl.2010.10.118" @default.
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