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- W2022151539 abstract "Effect of chronic thyrotropin-releasing hormone (TRH) treatment on the properties of spinal cord TRH-receptor was evaluated by Scatchard analysis of data on the saturation of specific binding of [methyl-His3-3H]TRH. Continuous subcutaneous administration of TRH (0.51 +/- 0.02 mg/kg/day) via an Alzetmini osmotic pump for ten days led to a substantial increase in both Bmax (control: 20.0 +/- 2.9, treated: 36.1 +/- 2.8 fmol/mg protein, P = 0.0018) and Kd (control: 7.6 +/- 0.8 treated: 11.7 +/- 1.8 nM, P = 0.0349) of the binding sites. These data suggest that chronic TRH treatment may not induce desensitization of physiologic/pharmacologic responses of TRH in the spinal cord." @default.
- W2022151539 created "2016-06-24" @default.
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- W2022151539 date "1989-09-01" @default.
- W2022151539 modified "2023-09-27" @default.
- W2022151539 title "Chronic thyrotropin-releasing hormone decreases the affinity and increases the number of its own receptor in the spinal cord" @default.
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- W2022151539 doi "https://doi.org/10.1016/0304-3940(89)90118-3" @default.
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