FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022151688> ?p ?o ?g. }

• W2022151688 endingPage "8475" @default.
• W2022151688 startingPage "8470" @default.
• W2022151688 abstract "SKP1-Cullin1-F-box protein (SCF) ubiquitin-ligases regulate numerous aspects of eukaryotic growth and development. Cullin-Associated and Neddylation-Dissociated (CAND1) modulates SCF function through its interactions with the CUL1 subunit. Although biochemical studies with human CAND1 suggested that CAND1 plays a negative regulatory role by sequestering CUL1 and preventing SCF complex assembly, genetic studies in Arabidopsis have shown that cand1 mutants exhibit reduced SCF activity, demonstrating that CAND1 is required for optimal SCF function in vivo. Together, these genetic and biochemical studies have suggested a model of CAND1-mediated cycles of SCF complex assembly and disassembly. Here, using the SCF(TIR1) complex of the Arabidopsis auxin response pathway, we test the SCF cycling model with Arabidopsis mutant derivatives of CAND1 and CUL1 that have opposing effects on the CAND1-CUL1 interaction. We find that the disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex. In contrast, stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance. The fact that both decreased and increased CAND1-CUL1 interactions result in reduced SCF(TIR1) activity in vivo strongly supports the hypothesis that CAND1-mediated cycling is required for optimal SCF function." @default.
• W2022151688 created "2016-06-24" @default.
• W2022151688 creator A5005477316 @default.
• W2022151688 creator A5043774560 @default.
• W2022151688 creator A5052864588 @default.
• W2022151688 creator A5055875257 @default.
• W2022151688 creator A5065716806 @default.
• W2022151688 creator A5067493243 @default.
• W2022151688 date "2008-06-17" @default.
• W2022151688 modified "2023-09-25" @default.
• W2022151688 title "Genetic analysis of CAND1–CUL1 interactions in <i>Arabidopsis</i> supports a role for CAND1-mediated cycling of the SCF ^TIR1 complex" @default.
• W2022151688 cites W1541556706 @default.
• W2022151688 cites W1698064934 @default.
• W2022151688 cites W1769736739 @default.
• W2022151688 cites W1971238944 @default.
• W2022151688 cites W1991000990 @default.
• W2022151688 cites W1992715180 @default.
• W2022151688 cites W1994755995 @default.
• W2022151688 cites W2007422896 @default.
• W2022151688 cites W2013057562 @default.
• W2022151688 cites W2032590709 @default.
• W2022151688 cites W2035599991 @default.
• W2022151688 cites W2094021381 @default.
• W2022151688 cites W2101913031 @default.
• W2022151688 cites W2109446031 @default.
• W2022151688 cites W2110311890 @default.
• W2022151688 cites W2112052713 @default.
• W2022151688 cites W2121477827 @default.
• W2022151688 cites W2126783861 @default.
• W2022151688 cites W2126863927 @default.
• W2022151688 cites W2129622260 @default.
• W2022151688 cites W2135339359 @default.
• W2022151688 cites W2140074505 @default.
• W2022151688 cites W2140919652 @default.
• W2022151688 cites W2145708194 @default.
• W2022151688 cites W2172095542 @default.
• W2022151688 cites W4252653907 @default.
• W2022151688 doi "https://doi.org/10.1073/pnas.0804144105" @default.
• W2022151688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2448860" @default.
• W2022151688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18550827" @default.
• W2022151688 hasPublicationYear "2008" @default.
• W2022151688 type Work @default.
• W2022151688 sameAs 2022151688 @default.
• W2022151688 citedByCount "54" @default.
• W2022151688 countsByYear W20221516882012 @default.
• W2022151688 countsByYear W20221516882013 @default.
• W2022151688 countsByYear W20221516882014 @default.
• W2022151688 countsByYear W20221516882016 @default.
• W2022151688 countsByYear W20221516882017 @default.
• W2022151688 countsByYear W20221516882018 @default.
• W2022151688 countsByYear W20221516882019 @default.
• W2022151688 countsByYear W20221516882020 @default.
• W2022151688 countsByYear W20221516882021 @default.
• W2022151688 countsByYear W20221516882022 @default.
• W2022151688 countsByYear W20221516882023 @default.
• W2022151688 crossrefType "journal-article" @default.
• W2022151688 hasAuthorship W2022151688A5005477316 @default.
• W2022151688 hasAuthorship W2022151688A5043774560 @default.
• W2022151688 hasAuthorship W2022151688A5052864588 @default.
• W2022151688 hasAuthorship W2022151688A5055875257 @default.
• W2022151688 hasAuthorship W2022151688A5065716806 @default.
• W2022151688 hasAuthorship W2022151688A5067493243 @default.
• W2022151688 hasBestOaLocation W20221516881 @default.
• W2022151688 hasConcept C104317684 @default.
• W2022151688 hasConcept C131312102 @default.
• W2022151688 hasConcept C134459356 @default.
• W2022151688 hasConcept C143065580 @default.
• W2022151688 hasConcept C162863750 @default.
• W2022151688 hasConcept C185592680 @default.
• W2022151688 hasConcept C25602115 @default.
• W2022151688 hasConcept C2775868145 @default.
• W2022151688 hasConcept C2779491563 @default.
• W2022151688 hasConcept C55493867 @default.
• W2022151688 hasConcept C86803240 @default.
• W2022151688 hasConcept C95444343 @default.
• W2022151688 hasConceptScore W2022151688C104317684 @default.
• W2022151688 hasConceptScore W2022151688C131312102 @default.
• W2022151688 hasConceptScore W2022151688C134459356 @default.
• W2022151688 hasConceptScore W2022151688C143065580 @default.
• W2022151688 hasConceptScore W2022151688C162863750 @default.
• W2022151688 hasConceptScore W2022151688C185592680 @default.
• W2022151688 hasConceptScore W2022151688C25602115 @default.
• W2022151688 hasConceptScore W2022151688C2775868145 @default.
• W2022151688 hasConceptScore W2022151688C2779491563 @default.
• W2022151688 hasConceptScore W2022151688C55493867 @default.
• W2022151688 hasConceptScore W2022151688C86803240 @default.
• W2022151688 hasConceptScore W2022151688C95444343 @default.
• W2022151688 hasIssue "24" @default.
• W2022151688 hasLocation W20221516881 @default.
• W2022151688 hasLocation W20221516882 @default.
• W2022151688 hasLocation W20221516883 @default.
• W2022151688 hasLocation W20221516884 @default.
• W2022151688 hasOpenAccess W2022151688 @default.
• W2022151688 hasPrimaryLocation W20221516881 @default.
• W2022151688 hasRelatedWork W1501553911 @default.
• W2022151688 hasRelatedWork W1995520312 @default.
• W2022151688 hasRelatedWork W1996110479 @default.
• W2022151688 hasRelatedWork W2055000819 @default.

• next