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- W2022152049 abstract "BACKGROUND: The clearance of D+ red blood cells (RBCs) from the circulation in D– individuals mediated by passively administered anti‐D occurs by opsonization with the antibody and subsequent removal in the spleen. Few data exist on the kinetics of clearance of large volumes of D+ RBCs from the maternal circulation by anti‐D in clinical cases of massive fetomaternal hemorrhage (FMH). CASE REPORT: A 33‐year‐old D– woman delivered a D+ female infant by emergency cesarean section for suspected fetal anemia. A massive FMH, initially estimated to be approximately 142 mL of RBCs, was found. In addition to the standard dose of intramuscular (IM) anti‐D (300 μg) given immediately after delivery, 2700 μg of anti‐D was administered intravenously (IV). The clearance of D+ fetal cells from the maternal circulation was monitored by flow cytometry in samples obtained on a daily basis using anti‐D. The mother had no detectable anti‐D 6 months after delivery. RESULTS: No clearance of fetal cells was apparent after the insufficient dose of IM anti‐D. The IV administration of anti‐D caused accelerated clearance of D+ fetal RBCs with a t ½ of 24.5 hours. D+ reticulocytes comprised 4.2 percent of all D+ cells in the maternal circulation at delivery suggesting acute fetal blood loss. CONCLUSIONS: The approach used in this report allowed a detailed analysis of the kinetics related to the clearance of fetal D+ RBCs. Simultaneous measurements of fetal reticulocytes and fetal RBCs in maternal blood may establish the timing of an FMH." @default.
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- W2022152049 date "2008-07-29" @default.
- W2022152049 modified "2023-10-16" @default.
- W2022152049 title "Massive fetomaternal hemorrhage: clearance of fetal red blood cells after intravenous anti-D prophylaxis monitored by flow cytometry" @default.
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- W2022152049 doi "https://doi.org/10.1111/j.1537-2995.2008.01740.x" @default.
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