Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022152057> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2022152057 endingPage "302A" @default.
- W2022152057 startingPage "302A" @default.
- W2022152057 abstract "Thrombus formation at sites of vascular injury provides cytokines, growth factors, and biodegradable matrix for cellular migration, proliferation, and matrix synthesis. We hypothesized that potent limitation of thrombus deposition following coronary arterial injury would significantly attenuate restenotic neointimal formation. Following oversized metallic coil implantation, 26 domestic pigs received either recombinant PEG Hirudin, (7 animals, 1 mg/kg IV bolus, 0.1 mg/kg/hr IV for 5 days) with a goal of keeping the ACT at 200 seconds, or placebo (12 animals). Survival until euthanasia was 28 ± 2 days. Linear regression models were constructed for planimetered mean neointimal (NI) thickness vs. mean vascular injury score (INJ).GroupHirudinControlpINJ2.1 ± 0.52.1 ± 0.7NSNI (mm)0.44 ± 0.190.71 ± 0.36<0.01 The neointima vs. injury regression equations for each group showed statistically significant differences in intercept, but not slope: Hirudin: NI = 0.35 × INJ – 030, r = 0.86. Control: NI = 0.43 × INJ – 018, r = 0.81. rPEG Hirudin administered early and in doses sufficient to maintain the activated clotting time at 200 seconds decreased the mean NI by 0.27 mm, a difference that would be angiographically detectable and clinically significant." @default.
- W2022152057 created "2016-06-24" @default.
- W2022152057 creator A5045846939 @default.
- W2022152057 creator A5051142287 @default.
- W2022152057 creator A5062156561 @default.
- W2022152057 creator A5079123919 @default.
- W2022152057 creator A5086188803 @default.
- W2022152057 date "1995-02-01" @default.
- W2022152057 modified "2023-09-25" @default.
- W2022152057 title "984-24 Chronic Hirudin Infusion Reduces Neointimal Thickening After Injury in a Porcine Coronary Model" @default.
- W2022152057 doi "https://doi.org/10.1016/0735-1097(95)92712-e" @default.
- W2022152057 hasPublicationYear "1995" @default.
- W2022152057 type Work @default.
- W2022152057 sameAs 2022152057 @default.
- W2022152057 citedByCount "1" @default.
- W2022152057 crossrefType "journal-article" @default.
- W2022152057 hasAuthorship W2022152057A5045846939 @default.
- W2022152057 hasAuthorship W2022152057A5051142287 @default.
- W2022152057 hasAuthorship W2022152057A5062156561 @default.
- W2022152057 hasAuthorship W2022152057A5079123919 @default.
- W2022152057 hasAuthorship W2022152057A5086188803 @default.
- W2022152057 hasConcept C126322002 @default.
- W2022152057 hasConcept C126894567 @default.
- W2022152057 hasConcept C141071460 @default.
- W2022152057 hasConcept C164705383 @default.
- W2022152057 hasConcept C2776301958 @default.
- W2022152057 hasConcept C2776710957 @default.
- W2022152057 hasConcept C2777292125 @default.
- W2022152057 hasConcept C2777339539 @default.
- W2022152057 hasConcept C2777565915 @default.
- W2022152057 hasConcept C2778271848 @default.
- W2022152057 hasConcept C2778283817 @default.
- W2022152057 hasConcept C2778583881 @default.
- W2022152057 hasConcept C2778810321 @default.
- W2022152057 hasConcept C2779161974 @default.
- W2022152057 hasConcept C2780400711 @default.
- W2022152057 hasConcept C2781362458 @default.
- W2022152057 hasConcept C42219234 @default.
- W2022152057 hasConcept C500558357 @default.
- W2022152057 hasConcept C71924100 @default.
- W2022152057 hasConcept C89560881 @default.
- W2022152057 hasConceptScore W2022152057C126322002 @default.
- W2022152057 hasConceptScore W2022152057C126894567 @default.
- W2022152057 hasConceptScore W2022152057C141071460 @default.
- W2022152057 hasConceptScore W2022152057C164705383 @default.
- W2022152057 hasConceptScore W2022152057C2776301958 @default.
- W2022152057 hasConceptScore W2022152057C2776710957 @default.
- W2022152057 hasConceptScore W2022152057C2777292125 @default.
- W2022152057 hasConceptScore W2022152057C2777339539 @default.
- W2022152057 hasConceptScore W2022152057C2777565915 @default.
- W2022152057 hasConceptScore W2022152057C2778271848 @default.
- W2022152057 hasConceptScore W2022152057C2778283817 @default.
- W2022152057 hasConceptScore W2022152057C2778583881 @default.
- W2022152057 hasConceptScore W2022152057C2778810321 @default.
- W2022152057 hasConceptScore W2022152057C2779161974 @default.
- W2022152057 hasConceptScore W2022152057C2780400711 @default.
- W2022152057 hasConceptScore W2022152057C2781362458 @default.
- W2022152057 hasConceptScore W2022152057C42219234 @default.
- W2022152057 hasConceptScore W2022152057C500558357 @default.
- W2022152057 hasConceptScore W2022152057C71924100 @default.
- W2022152057 hasConceptScore W2022152057C89560881 @default.
- W2022152057 hasIssue "2" @default.
- W2022152057 hasLocation W20221520571 @default.
- W2022152057 hasOpenAccess W2022152057 @default.
- W2022152057 hasPrimaryLocation W20221520571 @default.
- W2022152057 hasRelatedWork W1999841380 @default.
- W2022152057 hasRelatedWork W2002638971 @default.
- W2022152057 hasRelatedWork W2022152057 @default.
- W2022152057 hasRelatedWork W2033481411 @default.
- W2022152057 hasRelatedWork W2076474436 @default.
- W2022152057 hasRelatedWork W2080466794 @default.
- W2022152057 hasRelatedWork W2115535897 @default.
- W2022152057 hasRelatedWork W2347252473 @default.
- W2022152057 hasRelatedWork W2410308796 @default.
- W2022152057 hasRelatedWork W2558965443 @default.
- W2022152057 hasVolume "25" @default.
- W2022152057 isParatext "false" @default.
- W2022152057 isRetracted "false" @default.
- W2022152057 magId "2022152057" @default.
- W2022152057 workType "article" @default.