Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022152667> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2022152667 endingPage "196" @default.
- W2022152667 startingPage "188" @default.
- W2022152667 abstract "Abstract Patients initially diagnosed with type 1 von Willebrand disease (VWD) have been reclassified as type 2 after a more exhaustive analysis in several studies. Our study's objectives were (1) to reanalyze patients that were previously diagnosed as type 1 to achieve a more accurate diagnosis and (2) to compare the von Willebrand factor (VWF) ristocetin cofactor assay (VWF:RCo) and the VWF collagen binding assay (VWF:CB) in order to evaluate the possibility of replacing the former assay with the latter in the diagnosis of VWD. Twenty‐one patients from two large unrelated families and 104 normal controls were studied. VWF:Ag, VWF:RCo, FVIII coagulant activity (FVIII:C), bleeding time (BT), PFA 100 , and multimeric analysis of VWF were tested. Genetic analysis by sequencing exon 28 on the VWF gene was also carried out. Patients presented lower levels of VWF:Ag and VWF:RCo, a dissociation between VWF:RCo/VWF:Ag, and the presence of all sizes of multimers in plasma VWF. The results for VWF:CB varied depending on the type of collagen used. The genetic analysis showed that the mutation R1374C is responsible for type 2M VWD. A high frequency of the R1374C mutation is observed in northwestern Spain (Galicia). Some types of 2M VWD are misdiagnosed as type 1 VWD. The VWF:CB (with type I collagen) assay was unable to discriminate defective platelet binding of the R1374C VWF. This confirms that VWF:CB cannot substitute for VWF:RCo, and both should be tested when diagnosing VWD. Am. J. Hematol. 80:188–196, 2005. © 2005 Wiley‐Liss, Inc." @default.
- W2022152667 created "2016-06-24" @default.
- W2022152667 creator A5003343762 @default.
- W2022152667 creator A5025798042 @default.
- W2022152667 creator A5026327941 @default.
- W2022152667 creator A5029148813 @default.
- W2022152667 creator A5038867819 @default.
- W2022152667 creator A5043093488 @default.
- W2022152667 creator A5083964755 @default.
- W2022152667 date "2005-10-24" @default.
- W2022152667 modified "2023-10-18" @default.
- W2022152667 title "von Willebrand disease R1374C: Type 2A or 2M? A challenge to the revised classification. High frequency in the northwest of Spain (Galicia)" @default.
- W2022152667 cites W1581087233 @default.
- W2022152667 cites W1588902084 @default.
- W2022152667 cites W1602381906 @default.
- W2022152667 cites W190408506 @default.
- W2022152667 cites W1916695978 @default.
- W2022152667 cites W1963508251 @default.
- W2022152667 cites W1995971365 @default.
- W2022152667 cites W2029699184 @default.
- W2022152667 cites W2038718616 @default.
- W2022152667 cites W2053803264 @default.
- W2022152667 cites W2122027974 @default.
- W2022152667 cites W2152293695 @default.
- W2022152667 cites W2425002376 @default.
- W2022152667 cites W28685297 @default.
- W2022152667 cites W4296928923 @default.
- W2022152667 cites W4318470454 @default.
- W2022152667 cites W73293566 @default.
- W2022152667 doi "https://doi.org/10.1002/ajh.20470" @default.
- W2022152667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16247740" @default.
- W2022152667 hasPublicationYear "2005" @default.
- W2022152667 type Work @default.
- W2022152667 sameAs 2022152667 @default.
- W2022152667 citedByCount "33" @default.
- W2022152667 countsByYear W20221526672012 @default.
- W2022152667 countsByYear W20221526672016 @default.
- W2022152667 countsByYear W20221526672017 @default.
- W2022152667 countsByYear W20221526672018 @default.
- W2022152667 countsByYear W20221526672019 @default.
- W2022152667 countsByYear W20221526672020 @default.
- W2022152667 countsByYear W20221526672021 @default.
- W2022152667 countsByYear W20221526672022 @default.
- W2022152667 countsByYear W20221526672023 @default.
- W2022152667 crossrefType "journal-article" @default.
- W2022152667 hasAuthorship W2022152667A5003343762 @default.
- W2022152667 hasAuthorship W2022152667A5025798042 @default.
- W2022152667 hasAuthorship W2022152667A5026327941 @default.
- W2022152667 hasAuthorship W2022152667A5029148813 @default.
- W2022152667 hasAuthorship W2022152667A5038867819 @default.
- W2022152667 hasAuthorship W2022152667A5043093488 @default.
- W2022152667 hasAuthorship W2022152667A5083964755 @default.
- W2022152667 hasBestOaLocation W20221526671 @default.
- W2022152667 hasConcept C126322002 @default.
- W2022152667 hasConcept C153911025 @default.
- W2022152667 hasConcept C203014093 @default.
- W2022152667 hasConcept C2776057759 @default.
- W2022152667 hasConcept C2778780528 @default.
- W2022152667 hasConcept C2779394231 @default.
- W2022152667 hasConcept C2779936836 @default.
- W2022152667 hasConcept C71924100 @default.
- W2022152667 hasConcept C86803240 @default.
- W2022152667 hasConcept C89560881 @default.
- W2022152667 hasConceptScore W2022152667C126322002 @default.
- W2022152667 hasConceptScore W2022152667C153911025 @default.
- W2022152667 hasConceptScore W2022152667C203014093 @default.
- W2022152667 hasConceptScore W2022152667C2776057759 @default.
- W2022152667 hasConceptScore W2022152667C2778780528 @default.
- W2022152667 hasConceptScore W2022152667C2779394231 @default.
- W2022152667 hasConceptScore W2022152667C2779936836 @default.
- W2022152667 hasConceptScore W2022152667C71924100 @default.
- W2022152667 hasConceptScore W2022152667C86803240 @default.
- W2022152667 hasConceptScore W2022152667C89560881 @default.
- W2022152667 hasIssue "3" @default.
- W2022152667 hasLocation W20221526671 @default.
- W2022152667 hasLocation W20221526672 @default.
- W2022152667 hasOpenAccess W2022152667 @default.
- W2022152667 hasPrimaryLocation W20221526671 @default.
- W2022152667 hasRelatedWork W1986472887 @default.
- W2022152667 hasRelatedWork W2002544052 @default.
- W2022152667 hasRelatedWork W2047175704 @default.
- W2022152667 hasRelatedWork W2051832959 @default.
- W2022152667 hasRelatedWork W2104430226 @default.
- W2022152667 hasRelatedWork W2119937857 @default.
- W2022152667 hasRelatedWork W2129387929 @default.
- W2022152667 hasRelatedWork W2394870424 @default.
- W2022152667 hasRelatedWork W2897203814 @default.
- W2022152667 hasRelatedWork W3109596323 @default.
- W2022152667 hasVolume "80" @default.
- W2022152667 isParatext "false" @default.
- W2022152667 isRetracted "false" @default.
- W2022152667 magId "2022152667" @default.
- W2022152667 workType "article" @default.