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• W2022153734 abstract "The interaction of CT-DNA with the drug mesalamine (5-ASA) at physiological pH has been investigated by absorption, emission, circular dichroism (CD), cyclic voltammetry (CV), viscosity studies and molecular modeling. Thermodynamic parameters (ΔH>0 and ΔS<0) indicated that hydrogen bond and van der Waals play main roles in the binding of 5-ASA to CT-DNA. Ethidium bromide (EB) displacement studies revealed that 5-ASA did not have any effect on ethidium bromide (EB) bound DNA which is indicative of groove binding. The results obtained from experimental and molecular modeling showed that 5-ASA is a minor groove binder of DNA and preferentially binds to GC rich regions." @default.
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• W2022153734 date "2013-11-01" @default.
• W2022153734 modified "2023-10-03" @default.
• W2022153734 title "Study on the interaction of the drug mesalamine with calf thymus DNA using molecular docking and spectroscopic techniques" @default.
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• W2022153734 doi "https://doi.org/10.1016/j.jphotobiol.2013.08.005" @default.
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