FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022154088> ?p ?o ?g. }

• W2022154088 endingPage "1132" @default.
• W2022154088 startingPage "1125" @default.
• W2022154088 abstract "Islet cell loss in the pancreas results in diabetes. A noninvasive method that measures islet cell loss and also tracks the fate of transplanted islets would facilitate the development of novel therapeutics and improve the management of diabetes. We describe a novel dopamine D₂/D₃ receptor (D₂/D₃R)–based PET method to study islet cells in the rat pancreas and in islet cell transplantation. <b>Methods:</b>¹⁸F-fallypride binding to isolated rat islets and pancreas was evaluated in the absence and presence of the D₂/D₃R inhibitor haloperidol. After intravenous ¹⁸F-fallypride (28–37 MBq) administration, normal rats and rats pretreated with haloperidol were imaged in a PET/CT scanner and subsequently studied ex vivo for ¹⁸F-fallypride localization in the pancreas. A streptozotocin-treated diabetic rat model was used to study localization of ¹⁸F-fallypride in the pancreas, in vitro and ex vivo. Rat islet cells were transplanted into the spleen and visualized using ¹⁸F-fallypride PET. <b>Results:</b>¹⁸F-fallypride bound to isolated islet cells and pancreatic sections with an endocrine or exocrine selectivity of approximately 4; selectivity was reduced by haloperidol, suggesting that binding was D₂/D₃R-specific. Chemical destruction of islets by streptozotocin decreased ¹⁸F-fallypride binding in pancreas by greater than 50%, paralleling the decrease in insulin immunostaining. Uptake of ¹⁸F-fallypride in the pancreas was confirmed by radiochromatography and was 0.05% injected dose/cm³ as measured by PET/CT. The ratio of ¹⁸F-fallypride uptake in the pancreas to reference tissue (erector spinae muscle) was 5.5. Rat islets transplanted into the spleen were visualized in vivo by ¹⁸F-fallypride and confirmed by immunostaining. The ratio of spleen-transplanted islets to erector spinae muscle was greater than 5, compared with a ratio of 2.8 in untransplanted rats. <b>Conclusion:</b> These studies demonstrate the potential utility of ¹⁸F-fallypride as a PET agent for islet cells." @default.
• W2022154088 created "2016-06-24" @default.
• W2022154088 creator A5001937212 @default.
• W2022154088 creator A5020767222 @default.
• W2022154088 creator A5022592954 @default.
• W2022154088 creator A5050240366 @default.
• W2022154088 creator A5050432695 @default.
• W2022154088 creator A5051299945 @default.
• W2022154088 creator A5054767778 @default.
• W2022154088 creator A5071452254 @default.
• W2022154088 creator A5073604356 @default.
• W2022154088 creator A5085298972 @default.
• W2022154088 date "2011-06-16" @default.
• W2022154088 modified "2023-09-27" @default.
• W2022154088 title "18F-Fallypride PET of Pancreatic Islets: In Vitro and In Vivo Rodent Studies" @default.
• W2022154088 cites W1967682927 @default.
• W2022154088 cites W1973413843 @default.
• W2022154088 cites W1973974623 @default.
• W2022154088 cites W1976403273 @default.
• W2022154088 cites W1976596170 @default.
• W2022154088 cites W1982922041 @default.
• W2022154088 cites W1987741625 @default.
• W2022154088 cites W1994339332 @default.
• W2022154088 cites W2003614535 @default.
• W2022154088 cites W2005845118 @default.
• W2022154088 cites W2006919788 @default.
• W2022154088 cites W2020357505 @default.
• W2022154088 cites W2031195694 @default.
• W2022154088 cites W2034522254 @default.
• W2022154088 cites W2052682390 @default.
• W2022154088 cites W2053271068 @default.
• W2022154088 cites W2060646764 @default.
• W2022154088 cites W2064671909 @default.
• W2022154088 cites W2066583605 @default.
• W2022154088 cites W2073119162 @default.
• W2022154088 cites W2075051046 @default.
• W2022154088 cites W2079598508 @default.
• W2022154088 cites W2092088378 @default.
• W2022154088 cites W2099885693 @default.
• W2022154088 cites W2109558978 @default.
• W2022154088 cites W2111170119 @default.
• W2022154088 cites W2144036500 @default.
• W2022154088 cites W2144283470 @default.
• W2022154088 cites W2149806925 @default.
• W2022154088 cites W2163631689 @default.
• W2022154088 cites W2167255449 @default.
• W2022154088 cites W2320222570 @default.
• W2022154088 doi "https://doi.org/10.2967/jnumed.111.088583" @default.
• W2022154088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21680697" @default.
• W2022154088 hasPublicationYear "2011" @default.
• W2022154088 type Work @default.
• W2022154088 sameAs 2022154088 @default.
• W2022154088 citedByCount "21" @default.
• W2022154088 countsByYear W20221540882012 @default.
• W2022154088 countsByYear W20221540882013 @default.
• W2022154088 countsByYear W20221540882014 @default.
• W2022154088 countsByYear W20221540882015 @default.
• W2022154088 countsByYear W20221540882016 @default.
• W2022154088 countsByYear W20221540882019 @default.
• W2022154088 countsByYear W20221540882021 @default.
• W2022154088 crossrefType "journal-article" @default.
• W2022154088 hasAuthorship W2022154088A5001937212 @default.
• W2022154088 hasAuthorship W2022154088A5020767222 @default.
• W2022154088 hasAuthorship W2022154088A5022592954 @default.
• W2022154088 hasAuthorship W2022154088A5050240366 @default.
• W2022154088 hasAuthorship W2022154088A5050432695 @default.
• W2022154088 hasAuthorship W2022154088A5051299945 @default.
• W2022154088 hasAuthorship W2022154088A5054767778 @default.
• W2022154088 hasAuthorship W2022154088A5071452254 @default.
• W2022154088 hasAuthorship W2022154088A5073604356 @default.
• W2022154088 hasAuthorship W2022154088A5085298972 @default.
• W2022154088 hasBestOaLocation W20221540881 @default.
• W2022154088 hasConcept C126322002 @default.
• W2022154088 hasConcept C134018914 @default.
• W2022154088 hasConcept C150903083 @default.
• W2022154088 hasConcept C165220095 @default.
• W2022154088 hasConcept C185592680 @default.
• W2022154088 hasConcept C207001950 @default.
• W2022154088 hasConcept C2778764654 @default.
• W2022154088 hasConcept C2779280383 @default.
• W2022154088 hasConcept C2779855799 @default.
• W2022154088 hasConcept C2780948584 @default.
• W2022154088 hasConcept C513476851 @default.
• W2022154088 hasConcept C555293320 @default.
• W2022154088 hasConcept C71924100 @default.
• W2022154088 hasConcept C86803240 @default.
• W2022154088 hasConceptScore W2022154088C126322002 @default.
• W2022154088 hasConceptScore W2022154088C134018914 @default.
• W2022154088 hasConceptScore W2022154088C150903083 @default.
• W2022154088 hasConceptScore W2022154088C165220095 @default.
• W2022154088 hasConceptScore W2022154088C185592680 @default.
• W2022154088 hasConceptScore W2022154088C207001950 @default.
• W2022154088 hasConceptScore W2022154088C2778764654 @default.
• W2022154088 hasConceptScore W2022154088C2779280383 @default.
• W2022154088 hasConceptScore W2022154088C2779855799 @default.
• W2022154088 hasConceptScore W2022154088C2780948584 @default.
• W2022154088 hasConceptScore W2022154088C513476851 @default.
• W2022154088 hasConceptScore W2022154088C555293320 @default.

• next