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- W2022154417 abstract "A conventional upper abdominal ultrasound study revealed a hypoechoic lesion, approximately 2 cm in diameter, in the body of the pancreas (Fig. 1). The main pancreatic duct was not dilated. The patient was a 50-year-old woman who, 10 years previously, had been treated by nephrectomy for a poorly differentiated renal cell carcinoma. Previous investigations had not revealed any evidence of recurrent disease and she did not have any symptoms of a hormone-secreting neoplasm. After intravenous injection of 2.4 mL of the echo-enhancer Sono Vue®, the lesion was shown to be hypervascular using echo-enhanced sonography with pulse inversion imaging (Fig. 2). This is a new procedure that shows promise for the differentiation of pancreatic tumors. Pancreatic carcinomas typically show a hypovascular pattern that correlates well with results from contrast-enhanced computed tomography scans and magnetic resonance scans. In contrast, metastases from renal cell carcinomas and neuroendocrine tumors are usually hypervascular when compared with the surrounding tissue. In the case described above, a metastasis from renal cell carcinoma was suspected and the diagnosis was confirmed by histology after surgical resection. Metastases in the pancreas are uncommon. In clinical studies, metastases only comprise approximately 3% of pancreatic tumors. At autopsy, however, pancreatic metastases can be detected in 3–10% of patients with advanced malignancies. Excluding cancers that spread from adjacent organs, most of these metastases arise from primary cancers in the lung, breast, skin (particularly melanoma), colon and kidney. Whereas patients with pancreatic metastases from lung and breast cancer usually have advanced disease, the pancreas appears to be a preferred site for metastases from renal cell carcinoma. For example, a minority of the latter metastases are ‘solitary’ with the potential for cure by surgical excision. Another feature of metastases from renal cell carcinoma is the prolonged interval between nephrectomy and the diagnosis of metastases. In some studies, this interval has a mean duration of approximately 10 years." @default.
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- W2022154417 date "2004-10-01" @default.
- W2022154417 modified "2023-09-25" @default.
- W2022154417 title "Hepatobiliary and pancreatic: Pancreatic metastases" @default.
- W2022154417 doi "https://doi.org/10.1111/j.1440-1746.2004.03618.x" @default.
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