Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022157009> ?p ?o ?g. }
- W2022157009 endingPage "436" @default.
- W2022157009 startingPage "423" @default.
- W2022157009 abstract "Purpose of review This review presents our current understanding of the way metabolic acidosis induces calcium efflux from bone, and in the process, buffers additional systemic hydrogen ions associated with acidosis. Recent findings Acid-induced changes in bone mineral are consistent with a role for bone as a proton buffer. In response to metabolic acidosis in an in-vitro bone organ culture system, we observed a fall in mineral sodium, potassium, carbonate and phosphate, which each buffer protons and in vivo should increase systemic pH towards the physiologic normal. Initially, metabolic acidosis stimulates physicochemical mineral dissolution and subsequently cell-mediated bone resorption. Acidosis suppresses the activity of bone-resorbing cells, osteoblasts, decreasing gene expression of specific matrix proteins and alkaline phosphatase activity. There is concomitant acid stimulation of prostaglandin production by osteoblasts, which acting in a paracrine manner increases synthesis of the osteoblastic receptor activator of nuclear factor kappa B ligand (RANKL). The acid induction of RANKL then stimulates osteoclastic activity and recruitment of new osteoclasts to promote bone resorption and buffering of the proton load. Both the regulation of RANKL and acid-induced calcium efflux from bone are mediated by prostaglandins. Summary Metabolic acidosis, which occurs during renal failure, renal insufficiency or renal tubular acidosis, results in decreased systemic pH and is associated with an increase in urine calcium excretion. The apparent protective function of bone to help maintain systemic pH, which has a clear survival advantage for mammals, will come partly at the expense of its mineral stores." @default.
- W2022157009 created "2016-06-24" @default.
- W2022157009 creator A5032092472 @default.
- W2022157009 creator A5065803455 @default.
- W2022157009 creator A5091483213 @default.
- W2022157009 date "2004-07-01" @default.
- W2022157009 modified "2023-10-18" @default.
- W2022157009 title "Mechanism of acid-induced bone resorption" @default.
- W2022157009 cites W1007045512 @default.
- W2022157009 cites W1482776146 @default.
- W2022157009 cites W1489071669 @default.
- W2022157009 cites W1770323589 @default.
- W2022157009 cites W1805084076 @default.
- W2022157009 cites W1828929058 @default.
- W2022157009 cites W1843675084 @default.
- W2022157009 cites W1890394592 @default.
- W2022157009 cites W1906025505 @default.
- W2022157009 cites W1965629988 @default.
- W2022157009 cites W1965981498 @default.
- W2022157009 cites W1969933834 @default.
- W2022157009 cites W1971165609 @default.
- W2022157009 cites W1972007605 @default.
- W2022157009 cites W1977875815 @default.
- W2022157009 cites W1980705355 @default.
- W2022157009 cites W1980755033 @default.
- W2022157009 cites W1982878609 @default.
- W2022157009 cites W1982910988 @default.
- W2022157009 cites W1985306175 @default.
- W2022157009 cites W1986175018 @default.
- W2022157009 cites W1987201579 @default.
- W2022157009 cites W1993840273 @default.
- W2022157009 cites W1998743945 @default.
- W2022157009 cites W2001745376 @default.
- W2022157009 cites W2010582901 @default.
- W2022157009 cites W2011985807 @default.
- W2022157009 cites W2012706765 @default.
- W2022157009 cites W2013242641 @default.
- W2022157009 cites W2018602999 @default.
- W2022157009 cites W2020912482 @default.
- W2022157009 cites W2021314611 @default.
- W2022157009 cites W2031126471 @default.
- W2022157009 cites W2032498181 @default.
- W2022157009 cites W2033691143 @default.
- W2022157009 cites W2033864326 @default.
- W2022157009 cites W2035391294 @default.
- W2022157009 cites W2039006169 @default.
- W2022157009 cites W2039809784 @default.
- W2022157009 cites W2045066287 @default.
- W2022157009 cites W2046495232 @default.
- W2022157009 cites W2047794431 @default.
- W2022157009 cites W2048164032 @default.
- W2022157009 cites W2048357511 @default.
- W2022157009 cites W2051568454 @default.
- W2022157009 cites W2051668326 @default.
- W2022157009 cites W2053595085 @default.
- W2022157009 cites W2054629699 @default.
- W2022157009 cites W2055067737 @default.
- W2022157009 cites W2056795959 @default.
- W2022157009 cites W2059115098 @default.
- W2022157009 cites W2061097390 @default.
- W2022157009 cites W2064073091 @default.
- W2022157009 cites W2065754817 @default.
- W2022157009 cites W2065763865 @default.
- W2022157009 cites W2066086678 @default.
- W2022157009 cites W2067050197 @default.
- W2022157009 cites W2069566190 @default.
- W2022157009 cites W2075348958 @default.
- W2022157009 cites W2076650236 @default.
- W2022157009 cites W2078948216 @default.
- W2022157009 cites W2078993681 @default.
- W2022157009 cites W2081232429 @default.
- W2022157009 cites W2084152511 @default.
- W2022157009 cites W2087688557 @default.
- W2022157009 cites W2093814876 @default.
- W2022157009 cites W2094250752 @default.
- W2022157009 cites W2095006639 @default.
- W2022157009 cites W2116564650 @default.
- W2022157009 cites W2121778907 @default.
- W2022157009 cites W2123758480 @default.
- W2022157009 cites W2134217200 @default.
- W2022157009 cites W2142341955 @default.
- W2022157009 cites W2143237072 @default.
- W2022157009 cites W2152264881 @default.
- W2022157009 cites W2156446545 @default.
- W2022157009 cites W2162998968 @default.
- W2022157009 cites W2164490070 @default.
- W2022157009 cites W2186519022 @default.
- W2022157009 cites W2216136197 @default.
- W2022157009 cites W2232407802 @default.
- W2022157009 cites W2248030979 @default.
- W2022157009 cites W2271752545 @default.
- W2022157009 cites W2281886794 @default.
- W2022157009 cites W2294813879 @default.
- W2022157009 cites W2314513230 @default.
- W2022157009 cites W2316916281 @default.
- W2022157009 cites W2335973242 @default.
- W2022157009 cites W2337947318 @default.
- W2022157009 cites W2338006860 @default.