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• W2022157249 abstract "The atrial natriuretic peptide (ANP) gene is expressed in several extraatrial tissues in which ANP may be involved in the regulation of autocrine or paracrine functions. In the ovary, the synthesis of ANP, its binding sites, and a physiological role were found. The ANP system in the oviduct, however, is yet to be defined. The purpose of the present study was to determine whether the ANP system is present in the oviduct and then to define its function. The serial dilution curves of oviductal extracts in rat and rabbit were parallel to the standard curve of ANP. Molecular profiles using reverse phase HPLC indicated that the prohormone and processed circulating peptide were the main forms present. The immunoreactive ANP content of the oviduct was 27.07 ± 4.41 pg/mg tissue wet wt (1.19 ± 0.19 ng/oviduct; n = 10; at metestrus) in rats and 1.21 ± 0.12 pg/mg tissue wet wt (0.15 ± 0.01 ng/oviduct; n = 12) in rabbits. In adult 4-day cycling rats, the immunoreactive ANP contents in oviducts had a cyclic change characterized by the lowest level at proestrus (14.59 ± 3.24 pg/mg; n = 12). A distinct and strong ANP immunoreactivity was found in the mucosal layer of rat oviduct, and ANP messenger RNA was also detected in the oviduct by reverse transcriptase-PCR. Specific high affinity binding sites for iodinated rat ANP ([125I]rANP) were observed in the mucosal layer of the oviduct in rats and rabbits. Specific [125I]rANP bindings localized in the mucosal layer of rabbit oviduct showed an apparent dissociation constant (Kd) of 18.69± 5.55 nm and a maximal binding capacity of 14.85 ± 6.19 fmol/mm2. These specific [125I]rANP bindings were not reversed by des-[Gln18,Ser19,Gly20,Leu21,Gly22]ANP-(4–23) as a selective ligand of clearance receptor. Synthetic ANP inhibited both the frequency and amplitude of basal motility of rabbit oviduct in a dose-dependent manner. These results suggest that the oviduct has its own ANP system, and the system is involved in the regulation of oviductal motility." @default.
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• W2022157249 date "1997-06-01" @default.
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• W2022157249 title "Characterization of the Atrial Natriuretic Peptide System in the Oviduct*" @default.
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• W2022157249 doi "https://doi.org/10.1210/endo.138.6.5160" @default.
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