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- W2022157426 abstract "HLA class II antigens are not expressed on resting T cells, but upon activation, their expression is readily induced on most mature T cells. T cells derived from cord blood (CB), however, remain HLA class II− even when actively proliferating. To examine the reason for this deficiency, we have now tried to modulate HLA class II expression with three cytokine: interferon-γ (IFN-γ), tumor necrosis factor (TNF), and interleukin-1 (IL-1); all of which are known to modulate HLA class II expression in various cell types. Although CB T cells are not, in contrast to mature T cells, able to produce IFN-γ, IFN-γ did not have any effect on the amount of cell surface HLA-DR antigens. IL-1 was also without effect, but TNF increased the proportion of HLA-DR+ cells in both CB and adult peripheral blood (PBL)-derived T lymphoblasts. Northern blotting analysis of the HLA-DR mRNA levels revealed that in CB cells the levels were 5–6 times lower than in the PBL-derived lymphoblasts, indicating that the lower HLA-DR antigen expression in CB T cells is due to transcriptional regulation. Of the cytokines tested, only TNF had an effect on the steady-state HLA-DR mRNA levels, increasing the levels in both CB and PBL-derived T-blasts 2–3-fold." @default.
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- W2022157426 date "1989-02-01" @default.
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- W2022157426 title "Cytokine modulation of HLA-DR expression on proliferating cord blood T cells" @default.
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- W2022157426 doi "https://doi.org/10.1016/0165-2478(89)90083-7" @default.
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