Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022158061> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2022158061 abstract "Abstract Rationale Little is known about the why certain foods are allergenic. Previous research demonstrated that roasting enhances certain allergenic properties of peanuts. We investigated possible mechanisms that may explain divergence in in vitro and in vivo allergenicity of differentially roasted peanuts. Methods The major peanut allergens Ara h 1 and Ara h 2 were purified from raw (R), light roast (LR) and dark roast (DR) peanuts, subjected to digestion with pepsin and trypsin, analyzed for IgE binding and roasting induced sugar modifications. Also, whole peanut proteins extracted from R, LR, and DR samples were used to sensitize mice, which were prick skin tested with the same allergens to measure the degree of sensitization. Results Ara h 1 and Ara h 2, purified from roasted peanuts, are more resistant to digestive enzymes. A correlation is seen between IgE binding and sugar modifications on long lived fragments. Interestingly, the digestion pattern of Ara h 1 and Ara h 2 from R, LR and DR peanuts were different. Additionally, we determined that mice sensitized with roasted peanuts had higher skin test reactivity than mice sensitized with raw peanut proteins. Conclusions Our results indicate that many of the IgE binding, digestion resistant fragments are modified with sugar by-products that occur as a result of roasting. Also, in some occasions roasting alters the IgE-binding fragments that survive digestion, and therefore, quite possibly, the allergenic epitopes. These altered epitopes may be responsible for in vivo data that demonstrate mice are more likely to be sensitized to roasted than raw peanuts." @default.
- W2022158061 created "2016-06-24" @default.
- W2022158061 creator A5032004447 @default.
- W2022158061 creator A5034896356 @default.
- W2022158061 creator A5038162738 @default.
- W2022158061 creator A5047294294 @default.
- W2022158061 creator A5062590587 @default.
- W2022158061 creator A5082973851 @default.
- W2022158061 date "2004-02-01" @default.
- W2022158061 modified "2023-09-27" @default.
- W2022158061 title "Roasting may alter the IgE binding epitopes and sensitizing ability of peanut allergens*1" @default.
- W2022158061 doi "https://doi.org/10.1016/j.jaci.2003.12.561" @default.
- W2022158061 hasPublicationYear "2004" @default.
- W2022158061 type Work @default.
- W2022158061 sameAs 2022158061 @default.
- W2022158061 citedByCount "3" @default.
- W2022158061 countsByYear W20221580612012 @default.
- W2022158061 crossrefType "journal-article" @default.
- W2022158061 hasAuthorship W2022158061A5032004447 @default.
- W2022158061 hasAuthorship W2022158061A5034896356 @default.
- W2022158061 hasAuthorship W2022158061A5038162738 @default.
- W2022158061 hasAuthorship W2022158061A5047294294 @default.
- W2022158061 hasAuthorship W2022158061A5062590587 @default.
- W2022158061 hasAuthorship W2022158061A5082973851 @default.
- W2022158061 hasConcept C140327455 @default.
- W2022158061 hasConcept C141105273 @default.
- W2022158061 hasConcept C147789679 @default.
- W2022158061 hasConcept C150903083 @default.
- W2022158061 hasConcept C159654299 @default.
- W2022158061 hasConcept C185592680 @default.
- W2022158061 hasConcept C195616568 @default.
- W2022158061 hasConcept C203014093 @default.
- W2022158061 hasConcept C207001950 @default.
- W2022158061 hasConcept C207480886 @default.
- W2022158061 hasConcept C2776217527 @default.
- W2022158061 hasConcept C2777108408 @default.
- W2022158061 hasConcept C2780510475 @default.
- W2022158061 hasConcept C2780717550 @default.
- W2022158061 hasConcept C2781357212 @default.
- W2022158061 hasConcept C31903555 @default.
- W2022158061 hasConcept C43617362 @default.
- W2022158061 hasConcept C55493867 @default.
- W2022158061 hasConcept C86803240 @default.
- W2022158061 hasConceptScore W2022158061C140327455 @default.
- W2022158061 hasConceptScore W2022158061C141105273 @default.
- W2022158061 hasConceptScore W2022158061C147789679 @default.
- W2022158061 hasConceptScore W2022158061C150903083 @default.
- W2022158061 hasConceptScore W2022158061C159654299 @default.
- W2022158061 hasConceptScore W2022158061C185592680 @default.
- W2022158061 hasConceptScore W2022158061C195616568 @default.
- W2022158061 hasConceptScore W2022158061C203014093 @default.
- W2022158061 hasConceptScore W2022158061C207001950 @default.
- W2022158061 hasConceptScore W2022158061C207480886 @default.
- W2022158061 hasConceptScore W2022158061C2776217527 @default.
- W2022158061 hasConceptScore W2022158061C2777108408 @default.
- W2022158061 hasConceptScore W2022158061C2780510475 @default.
- W2022158061 hasConceptScore W2022158061C2780717550 @default.
- W2022158061 hasConceptScore W2022158061C2781357212 @default.
- W2022158061 hasConceptScore W2022158061C31903555 @default.
- W2022158061 hasConceptScore W2022158061C43617362 @default.
- W2022158061 hasConceptScore W2022158061C55493867 @default.
- W2022158061 hasConceptScore W2022158061C86803240 @default.
- W2022158061 hasLocation W20221580611 @default.
- W2022158061 hasOpenAccess W2022158061 @default.
- W2022158061 hasPrimaryLocation W20221580611 @default.
- W2022158061 hasRelatedWork W135093989 @default.
- W2022158061 hasRelatedWork W1977448573 @default.
- W2022158061 hasRelatedWork W1980302701 @default.
- W2022158061 hasRelatedWork W2000718765 @default.
- W2022158061 hasRelatedWork W2013794360 @default.
- W2022158061 hasRelatedWork W2051150011 @default.
- W2022158061 hasRelatedWork W2077768935 @default.
- W2022158061 hasRelatedWork W2092258950 @default.
- W2022158061 hasRelatedWork W2402104715 @default.
- W2022158061 hasRelatedWork W2783630444 @default.
- W2022158061 isParatext "false" @default.
- W2022158061 isRetracted "false" @default.
- W2022158061 magId "2022158061" @default.
- W2022158061 workType "article" @default.