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- W2022159056 endingPage "e24672" @default.
- W2022159056 startingPage "e24672" @default.
- W2022159056 abstract "Despite a conceptually simple mechanism of signaling, the JAK-STAT pathway exhibits considerable behavioral complexity. Computational pathway models are tools to investigate in detail signaling process. They integrate well with experimental studies, helping to explain molecular dynamics and to state new hypotheses, most often about the structure of interactions.A relatively small amount of experimental data is available for a JAK1/2-STAT1 variant of the pathway, hence, only several computational models were developed. Here we review a dominant approach of kinetic modeling of the JAK1/2-STAT1 pathway, based on ordinary differential equations. We also give a brief overview of attempts to computationally infer topology of this pathway." @default.
- W2022159056 created "2016-06-24" @default.
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- W2022159056 date "2013-07-15" @default.
- W2022159056 modified "2023-10-16" @default.
- W2022159056 title "Computational models of the JAK1/2-STAT1 signaling" @default.
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- W2022159056 doi "https://doi.org/10.4161/jkst.24672" @default.
- W2022159056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3772111" @default.
- W2022159056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24069559" @default.
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