Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022159376> ?p ?o ?g. }
- W2022159376 endingPage "7010" @default.
- W2022159376 startingPage "7004" @default.
- W2022159376 abstract "Post-translational modifications act as ‘on’ or ‘off’ switches causing downstream changes in gene transcription. Modifications such as trimethylation of lysine 27 on histone H3 (H3K27me3) cause repression of transcription and stable gene silencing, and its presence is associated with aggressive cancers of many types. We report here macrocyclic host-type compounds that can bind H3K27me3 preferentially over unmethylated H3K27, and characterize their binding affinities and selectivities using a convenient dye-displacement method. We also show that they can disrupt the protein–protein interaction of H3K27me3 with the chromobox homolog 7 (CBX7), a methyllysine reader protein, using fluorescence polarization. These results show that sub-micromolar potencies are achievable with this family of host compounds, and suggest the possibility of their use as new tools to induce the disruption of methyllysine-mediated protein–protein interactions and to report on lysine methylation in vitro." @default.
- W2022159376 created "2016-06-24" @default.
- W2022159376 creator A5001337359 @default.
- W2022159376 creator A5037136421 @default.
- W2022159376 creator A5044088982 @default.
- W2022159376 creator A5044864706 @default.
- W2022159376 creator A5053275557 @default.
- W2022159376 creator A5058596285 @default.
- W2022159376 creator A5061621194 @default.
- W2022159376 creator A5061690361 @default.
- W2022159376 creator A5067218486 @default.
- W2022159376 date "2013-11-01" @default.
- W2022159376 modified "2023-09-23" @default.
- W2022159376 title "Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7" @default.
- W2022159376 cites W14783732 @default.
- W2022159376 cites W151483826 @default.
- W2022159376 cites W1565600189 @default.
- W2022159376 cites W1971364991 @default.
- W2022159376 cites W1976962550 @default.
- W2022159376 cites W1977199336 @default.
- W2022159376 cites W1979187818 @default.
- W2022159376 cites W1982791788 @default.
- W2022159376 cites W1988515229 @default.
- W2022159376 cites W1992465391 @default.
- W2022159376 cites W1995652309 @default.
- W2022159376 cites W1997554416 @default.
- W2022159376 cites W1998008613 @default.
- W2022159376 cites W2004380688 @default.
- W2022159376 cites W2008618008 @default.
- W2022159376 cites W2010564453 @default.
- W2022159376 cites W2011387819 @default.
- W2022159376 cites W2012935454 @default.
- W2022159376 cites W2015735594 @default.
- W2022159376 cites W2017492512 @default.
- W2022159376 cites W2017625776 @default.
- W2022159376 cites W2019263897 @default.
- W2022159376 cites W2030059254 @default.
- W2022159376 cites W2033078160 @default.
- W2022159376 cites W2034619626 @default.
- W2022159376 cites W2038235796 @default.
- W2022159376 cites W2042080470 @default.
- W2022159376 cites W2052741109 @default.
- W2022159376 cites W2068146209 @default.
- W2022159376 cites W2075617973 @default.
- W2022159376 cites W2080586621 @default.
- W2022159376 cites W2083189685 @default.
- W2022159376 cites W2084295010 @default.
- W2022159376 cites W2084639301 @default.
- W2022159376 cites W2091703726 @default.
- W2022159376 cites W2096083625 @default.
- W2022159376 cites W2101139969 @default.
- W2022159376 cites W2106714479 @default.
- W2022159376 cites W2120121380 @default.
- W2022159376 cites W2121452217 @default.
- W2022159376 cites W2143658931 @default.
- W2022159376 cites W2148121673 @default.
- W2022159376 cites W2150496308 @default.
- W2022159376 cites W2156518222 @default.
- W2022159376 cites W2163211771 @default.
- W2022159376 cites W2163830357 @default.
- W2022159376 cites W2312657787 @default.
- W2022159376 cites W2315423922 @default.
- W2022159376 cites W2322307188 @default.
- W2022159376 doi "https://doi.org/10.1016/j.bmc.2013.09.024" @default.
- W2022159376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24100156" @default.
- W2022159376 hasPublicationYear "2013" @default.
- W2022159376 type Work @default.
- W2022159376 sameAs 2022159376 @default.
- W2022159376 citedByCount "39" @default.
- W2022159376 countsByYear W20221593762014 @default.
- W2022159376 countsByYear W20221593762015 @default.
- W2022159376 countsByYear W20221593762016 @default.
- W2022159376 countsByYear W20221593762017 @default.
- W2022159376 countsByYear W20221593762018 @default.
- W2022159376 countsByYear W20221593762019 @default.
- W2022159376 countsByYear W20221593762020 @default.
- W2022159376 countsByYear W20221593762021 @default.
- W2022159376 countsByYear W20221593762023 @default.
- W2022159376 crossrefType "journal-article" @default.
- W2022159376 hasAuthorship W2022159376A5001337359 @default.
- W2022159376 hasAuthorship W2022159376A5037136421 @default.
- W2022159376 hasAuthorship W2022159376A5044088982 @default.
- W2022159376 hasAuthorship W2022159376A5044864706 @default.
- W2022159376 hasAuthorship W2022159376A5053275557 @default.
- W2022159376 hasAuthorship W2022159376A5058596285 @default.
- W2022159376 hasAuthorship W2022159376A5061621194 @default.
- W2022159376 hasAuthorship W2022159376A5061690361 @default.
- W2022159376 hasAuthorship W2022159376A5067218486 @default.
- W2022159376 hasConcept C104317684 @default.
- W2022159376 hasConcept C11804247 @default.
- W2022159376 hasConcept C119056186 @default.
- W2022159376 hasConcept C119157956 @default.
- W2022159376 hasConcept C138885662 @default.
- W2022159376 hasConcept C179926584 @default.
- W2022159376 hasConcept C185592680 @default.
- W2022159376 hasConcept C2776016237 @default.
- W2022159376 hasConcept C2776745794 @default.
- W2022159376 hasConcept C33288867 @default.