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- W2022160106 endingPage "1072" @default.
- W2022160106 startingPage "1055" @default.
- W2022160106 abstract "The simple sustainable or 'eternal' cell model, assuming preservation of all proteins, is designed as a building block, a primitive element upon which one can build more complete functional cell models of various types, representing various species. In the modelling we emphasize the electrophysiological aspects, in part because these are a well-developed component of cell models and because membrane potentials and their fluctuations have been generally omitted from metabolically oriented cell models in the past. Fluctuations in membrane potential deserve heightened consideration because probably all cells have negative intracellular potentials and most cells demonstrate electrical activity with vesicular extrusion, receptor occupancy, as well as with stimulated excitation resulting in regenerative depolarization. The emphasis is on the balances of mass, charge, and of chemical species while accounting for substrate uptake, metabolism and metabolite loss from the cell. By starting with a primitive representation we emphasize the conservation ideas. As more advanced models are generated they must adhere to the same basic principles as are required for the most primitive incomplete model." @default.
- W2022160106 created "2016-06-24" @default.
- W2022160106 creator A5062325761 @default.
- W2022160106 date "2001-06-15" @default.
- W2022160106 modified "2023-10-16" @default.
- W2022160106 title "The modelling of a primitive ‘sustainable’ conservative cell" @default.
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- W2022160106 doi "https://doi.org/10.1098/rsta.2001.0821" @default.
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