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- W2022162216 abstract "A physiologically based pharmacokinetic (PBPK) model and program (called PostNatal) was developed which focuses on postnatal growth. Algorithms defining organ/tissue growth curves from birth through adulthood for male and female humans, dogs, rats, and mice are utilized to calculate the appropriate weight and blood flow for the internal organs/tissues. This Windows based program is actually four linked PBPK models with each PBPK model acting independently or totally integrated with the others through metabolism by first order or Michaelis-Menten kinetics. Data fitting is accomplished by a weighted least square regression algorithm. The model includes linkages for the simulation of pharmacodynamic (PD) effects." @default.
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- W2022162216 date "2008-09-01" @default.
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- W2022162216 title "Windows based general PBPK/PD modeling software" @default.
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- W2022162216 doi "https://doi.org/10.1016/j.compbiomed.2008.06.001" @default.
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