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• W2022163627 abstract "Context: Nicotine metabolite ratio (NMR) is linked with smoking behaviour and quitting, but little is known about the importance of UDP-glucuronosyltransferase metabolism phenotype on NMR.Objective: To investigate the relationship between NMR and UDP-glucuronosyltransferase phenotype in a Caucasian population.Methods: Urine samples from 260 smokers were measured by UPLC-MS/MS for cotinine (COT), 3′-hydroxycotinine, COT-glucuronide and 3′-hydroxycotinine-glucuronide. UDP-glucuronosyltransferase phenotype was assessed using the proportion of metabolites present as the glucuronide.Results: A correlation was found between NMR and UDP-glucuronosyltransferase phenotype for COT (males and females) and 3′-HC in females (p < 0.0001).Conclusion: NMR is clearly influenced by UDP-glucuronosyltransferase phenotype for COT in Caucasians." @default.
• W2022163627 created "2016-06-24" @default.
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• W2022163627 date "2014-11-06" @default.
• W2022163627 modified "2023-10-16" @default.
• W2022163627 title "Relationship between cotinine and trans-3′-hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers" @default.
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• W2022163627 doi "https://doi.org/10.3109/1354750x.2014.966254" @default.
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