FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022163785> ?p ?o ?g. }

• W2022163785 endingPage "1919" @default.
• W2022163785 startingPage "1911" @default.
• W2022163785 abstract "We have studied the ability of the neu tyrosine kinase to induce a signal for the activation of cell growth-regulated genes. Serum-starved NIH 3T3 cells expressing an epidermal growth factor receptor (EGF-R)/neu construct encoding a hybrid receptor protein were stimulated with EGF and the activation of the neu tyrosine kinase and stimulation of growth factor inducible genes were followed at the mRNA, protein, and activity levels, and compared to the corresponding responses in the neu proto-oncogene and oncogene expressing cells. Induction of the expression of jun mRNAs was an immediate early effect of EGF stimulation, followed by a marked increase in the biosynthesis of the fos/jun transcription factor complex and an increased transcription factor activity as measured by a recombinant transcription unit using chloramphenicol acetyltransferase assays. In distinction, elevated AP-1/PEA-1 activity in the absence of a significant increase in jun and fos expression was characteristic of the neu oncogene-expressing cells. The glucose transporter mRNA increased at 2 h of EGF stimulation and was associated with enhanced glucose transport of the EGF-treated cells. An increase of ornithine decarboxylase (ODC) mRNA and activity followed these changes. In contrast, serum-starved, EGF-treated neu proto-oncogene- and oncogene-expressing cells showed constitutively low and high glucose transporter and ODC activities, respectively. These findings demonstrate that the chimeric EGF-R/neu receptor is capable of activating the expression of both immediate early genes and biochemical activities associated with cell growth stimulation." @default.
• W2022163785 created "2016-06-24" @default.
• W2022163785 creator A5007027974 @default.
• W2022163785 creator A5013639072 @default.
• W2022163785 creator A5023660858 @default.
• W2022163785 creator A5046276726 @default.
• W2022163785 creator A5065169828 @default.
• W2022163785 date "1989-11-01" @default.
• W2022163785 modified "2023-10-09" @default.
• W2022163785 title "Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase." @default.
• W2022163785 cites W1509817645 @default.
• W2022163785 cites W1515192237 @default.
• W2022163785 cites W1616429637 @default.
• W2022163785 cites W1708424788 @default.
• W2022163785 cites W1714197903 @default.
• W2022163785 cites W1760280961 @default.
• W2022163785 cites W1965372133 @default.
• W2022163785 cites W1966099909 @default.
• W2022163785 cites W1966823692 @default.
• W2022163785 cites W1967004332 @default.
• W2022163785 cites W1967653587 @default.
• W2022163785 cites W1973033337 @default.
• W2022163785 cites W1974027176 @default.
• W2022163785 cites W1980065068 @default.
• W2022163785 cites W1985603777 @default.
• W2022163785 cites W1992139451 @default.
• W2022163785 cites W1995136152 @default.
• W2022163785 cites W2000371106 @default.
• W2022163785 cites W2003015952 @default.
• W2022163785 cites W2016620103 @default.
• W2022163785 cites W2017213758 @default.
• W2022163785 cites W2017692699 @default.
• W2022163785 cites W2018289835 @default.
• W2022163785 cites W2020790836 @default.
• W2022163785 cites W2021253208 @default.
• W2022163785 cites W2022162403 @default.
• W2022163785 cites W2027047605 @default.
• W2022163785 cites W2028387622 @default.
• W2022163785 cites W2042917826 @default.
• W2022163785 cites W2045798063 @default.
• W2022163785 cites W2051819610 @default.
• W2022163785 cites W2052977964 @default.
• W2022163785 cites W2053280162 @default.
• W2022163785 cites W2057094603 @default.
• W2022163785 cites W2058744360 @default.
• W2022163785 cites W2063116540 @default.
• W2022163785 cites W2072140252 @default.
• W2022163785 cites W2074568047 @default.
• W2022163785 cites W2074783201 @default.
• W2022163785 cites W2077492124 @default.
• W2022163785 cites W2094872845 @default.
• W2022163785 cites W2096996169 @default.
• W2022163785 cites W2097251483 @default.
• W2022163785 cites W2097794242 @default.
• W2022163785 cites W2100837269 @default.
• W2022163785 cites W2106628955 @default.
• W2022163785 cites W2120945020 @default.
• W2022163785 cites W2137150803 @default.
• W2022163785 cites W2144206181 @default.
• W2022163785 cites W2155963496 @default.
• W2022163785 cites W34093332 @default.
• W2022163785 cites W53330856 @default.
• W2022163785 cites W1810912511 @default.
• W2022163785 doi "https://doi.org/10.1083/jcb.109.5.1911" @default.
• W2022163785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2115885" @default.
• W2022163785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2572601" @default.
• W2022163785 hasPublicationYear "1989" @default.
• W2022163785 type Work @default.
• W2022163785 sameAs 2022163785 @default.
• W2022163785 citedByCount "81" @default.
• W2022163785 countsByYear W20221637852014 @default.
• W2022163785 countsByYear W20221637852016 @default.
• W2022163785 countsByYear W20221637852023 @default.
• W2022163785 crossrefType "journal-article" @default.
• W2022163785 hasAuthorship W2022163785A5007027974 @default.
• W2022163785 hasAuthorship W2022163785A5013639072 @default.
• W2022163785 hasAuthorship W2022163785A5023660858 @default.
• W2022163785 hasAuthorship W2022163785A5046276726 @default.
• W2022163785 hasAuthorship W2022163785A5065169828 @default.
• W2022163785 hasBestOaLocation W20221637851 @default.
• W2022163785 hasConcept C101544691 @default.
• W2022163785 hasConcept C121289238 @default.
• W2022163785 hasConcept C153911025 @default.
• W2022163785 hasConcept C170493617 @default.
• W2022163785 hasConcept C181199279 @default.
• W2022163785 hasConcept C2776362946 @default.
• W2022163785 hasConcept C42362537 @default.
• W2022163785 hasConcept C55493867 @default.
• W2022163785 hasConcept C62478195 @default.
• W2022163785 hasConcept C86803240 @default.
• W2022163785 hasConcept C95444343 @default.
• W2022163785 hasConceptScore W2022163785C101544691 @default.
• W2022163785 hasConceptScore W2022163785C121289238 @default.
• W2022163785 hasConceptScore W2022163785C153911025 @default.
• W2022163785 hasConceptScore W2022163785C170493617 @default.
• W2022163785 hasConceptScore W2022163785C181199279 @default.
• W2022163785 hasConceptScore W2022163785C2776362946 @default.
• W2022163785 hasConceptScore W2022163785C42362537 @default.

• next