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• W2022163852 abstract "Background . Patients afflicted with Alzheimer's disease (AD) exhibit a decrease in the cerebrospinal fluid (CSF) concentration of the 42 amino acid form of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>-amyloid (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>A</mml:mtext><mml:msub><mml:mi>β</mml:mi><mml:mrow><mml:mn>42</mml:mn></mml:mrow></mml:msub></mml:math>). However, a high discrepancy between different centers in measured<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>A</mml:mtext><mml:msub><mml:mi>β</mml:mi><mml:mrow><mml:mn>42</mml:mn></mml:mrow></mml:msub></mml:math>levels reduces the utility of this biomarker as a diagnostic tool and in monitoring the effect of disease modifying drugs. Preanalytical and analytical confounding factors were examined with respect to their effect on the measured<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>A</mml:mtext><mml:msub><mml:mi>β</mml:mi><mml:mrow><mml:mn>42</mml:mn></mml:mrow></mml:msub></mml:math>level. Methods . Aliquots of CSF samples were either treated differently prior to<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>A</mml:mtext><mml:msub><mml:mi>β</mml:mi><mml:mrow><mml:mn>42</mml:mn></mml:mrow></mml:msub></mml:math>measurement or analyzed using different commercially available xMAP or ELISA assays. Results . Confounding factors affecting CSF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>A</mml:mtext><mml:msub><mml:mi>β</mml:mi><mml:mrow><mml:mn>42</mml:mn></mml:mrow></mml:msub></mml:math>levels were storage in different types of test tubes, dilution with detergent-containing buffer, plasma contamination, heat treatment, and the origin of the immunoassays used for quantification. Conclusion . In order to conduct multicenter studies, a standardized protocol to minimize preanalytical and analytical confounding factors is warranted." @default.
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• W2022163852 date "2010-01-01" @default.
• W2022163852 modified "2023-10-16" @default.
• W2022163852 title "Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid" @default.
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• W2022163852 doi "https://doi.org/10.4061/2010/986310" @default.
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