FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022163946> ?p ?o ?g. }

• W2022163946 endingPage "168" @default.
• W2022163946 startingPage "163" @default.
• W2022163946 abstract "Reduced Expression of the Inhibitory Genes for Fas‐Mediated Apoptosis in Silicosis Patients: Takemi O tsuki , et al . Department of Hygiene, Kawasaki Medical School —Silicosis cases are characterized not only by respiratory disorders but by various immunological abnormalities, but the cellular biological effects of silica compounds on human lymphocytes have not been well investigated. Our previous studies revealed high serum soluble Fas (sFas) levels in silicosis patients without any clinical symptoms of autoimmune disease and the dominant expression of sFas mRNA in peripheral blood mononuclear cells (PBMC) derived from these patients. These observations indicate that dysregulation of the Fas gene may play an important role in the pathogenesis of the immunological abnormalities found in silicosis patients. Recently several molecules with inhibitory or regulatory effects on Fas‐mediated apoptosis have been identified and their cellular biological roles investigated. We examined the mRNA expression of inhibitory genes (TOSO, sentrin, and cFLIP), regulatory genes (CPAN and DFF45), and caspases (caspase‐1, ‐3, and ‐8) in PBMC derived from silicosis patients. The results showed a reduced expression of sentrin, cFLIP and DFF45 and an overexpression of caspase‐1. Nevertheless, considering the remarkable dominant expression of sFas in silicosis, the dysregulation of inhibitory genes and caspase‐1 may be evidence of a Fas‐mediated apoptotic pathway activated via the remaining membrane Fas molecules in the PBMC of silicosis patients." @default.
• W2022163946 created "2016-06-24" @default.
• W2022163946 creator A5037687748 @default.
• W2022163946 creator A5044079218 @default.
• W2022163946 creator A5065442140 @default.
• W2022163946 creator A5073261293 @default.
• W2022163946 creator A5077747530 @default.
• W2022163946 creator A5090560877 @default.
• W2022163946 date "2000-07-01" @default.
• W2022163946 modified "2023-09-28" @default.
• W2022163946 title "Reduced Expression of the Inhibitory Genes for Fas‐Mediated Apoptosis in Silicosis Patients" @default.
• W2022163946 cites W139547048 @default.
• W2022163946 cites W1965115872 @default.
• W2022163946 cites W1972805802 @default.
• W2022163946 cites W1977162479 @default.
• W2022163946 cites W2024103863 @default.
• W2022163946 cites W2037059030 @default.
• W2022163946 cites W2038055601 @default.
• W2022163946 cites W2040678840 @default.
• W2022163946 cites W2051916700 @default.
• W2022163946 cites W2057332167 @default.
• W2022163946 cites W2061497413 @default.
• W2022163946 cites W2064074285 @default.
• W2022163946 cites W2067419827 @default.
• W2022163946 cites W2070509529 @default.
• W2022163946 cites W2072041637 @default.
• W2022163946 cites W2076317085 @default.
• W2022163946 cites W2082259697 @default.
• W2022163946 cites W2084957243 @default.
• W2022163946 cites W2096757580 @default.
• W2022163946 cites W2118017831 @default.
• W2022163946 cites W2128175147 @default.
• W2022163946 cites W2132934513 @default.
• W2022163946 cites W2141410193 @default.
• W2022163946 cites W2156305166 @default.
• W2022163946 cites W2168336398 @default.
• W2022163946 cites W2442754154 @default.
• W2022163946 doi "https://doi.org/10.1539/joh.42.163" @default.
• W2022163946 hasPublicationYear "2000" @default.
• W2022163946 type Work @default.
• W2022163946 sameAs 2022163946 @default.
• W2022163946 citedByCount "16" @default.
• W2022163946 countsByYear W20221639462012 @default.
• W2022163946 countsByYear W20221639462014 @default.
• W2022163946 countsByYear W20221639462015 @default.
• W2022163946 countsByYear W20221639462016 @default.
• W2022163946 countsByYear W20221639462017 @default.
• W2022163946 crossrefType "journal-article" @default.
• W2022163946 hasAuthorship W2022163946A5037687748 @default.
• W2022163946 hasAuthorship W2022163946A5044079218 @default.
• W2022163946 hasAuthorship W2022163946A5065442140 @default.
• W2022163946 hasAuthorship W2022163946A5073261293 @default.
• W2022163946 hasAuthorship W2022163946A5077747530 @default.
• W2022163946 hasAuthorship W2022163946A5090560877 @default.
• W2022163946 hasBestOaLocation W20221639461 @default.
• W2022163946 hasConcept C104317684 @default.
• W2022163946 hasConcept C137061746 @default.
• W2022163946 hasConcept C142724271 @default.
• W2022163946 hasConcept C150194340 @default.
• W2022163946 hasConcept C190283241 @default.
• W2022163946 hasConcept C202751555 @default.
• W2022163946 hasConcept C203014093 @default.
• W2022163946 hasConcept C2777811718 @default.
• W2022163946 hasConcept C2780942790 @default.
• W2022163946 hasConcept C3031857 @default.
• W2022163946 hasConcept C31573885 @default.
• W2022163946 hasConcept C55493867 @default.
• W2022163946 hasConcept C71924100 @default.
• W2022163946 hasConcept C86803240 @default.
• W2022163946 hasConcept C98424977 @default.
• W2022163946 hasConceptScore W2022163946C104317684 @default.
• W2022163946 hasConceptScore W2022163946C137061746 @default.
• W2022163946 hasConceptScore W2022163946C142724271 @default.
• W2022163946 hasConceptScore W2022163946C150194340 @default.
• W2022163946 hasConceptScore W2022163946C190283241 @default.
• W2022163946 hasConceptScore W2022163946C202751555 @default.
• W2022163946 hasConceptScore W2022163946C203014093 @default.
• W2022163946 hasConceptScore W2022163946C2777811718 @default.
• W2022163946 hasConceptScore W2022163946C2780942790 @default.
• W2022163946 hasConceptScore W2022163946C3031857 @default.
• W2022163946 hasConceptScore W2022163946C31573885 @default.
• W2022163946 hasConceptScore W2022163946C55493867 @default.
• W2022163946 hasConceptScore W2022163946C71924100 @default.
• W2022163946 hasConceptScore W2022163946C86803240 @default.
• W2022163946 hasConceptScore W2022163946C98424977 @default.
• W2022163946 hasIssue "4" @default.
• W2022163946 hasLocation W20221639461 @default.
• W2022163946 hasOpenAccess W2022163946 @default.
• W2022163946 hasPrimaryLocation W20221639461 @default.
• W2022163946 hasRelatedWork W2009966535 @default.
• W2022163946 hasRelatedWork W2011179920 @default.
• W2022163946 hasRelatedWork W2037754829 @default.
• W2022163946 hasRelatedWork W2042809471 @default.
• W2022163946 hasRelatedWork W2071151379 @default.
• W2022163946 hasRelatedWork W2084363870 @default.
• W2022163946 hasRelatedWork W2188887289 @default.
• W2022163946 hasRelatedWork W2351839987 @default.
• W2022163946 hasRelatedWork W2353446510 @default.

• next