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• W2022164975 abstract "Nomura et al. [ [1] Nomura T. Inoue Y. Högl B. Uemura Y. Kitayama M. Abe T. et al. Relationship between 123I-MIBG scintigrams and REM sleep behavior disorder in Parkinson’s disease. Parkinsonism Relat Disord. 2010; 16: 683-685 Abstract Full Text Full Text PDF PubMed Scopus (53) Google Scholar ] recently reported that 123I-MIBG uptake was decreased in non-demented Parkinson’s disease (PD) patients with clinical REM sleep behavior disorder (RBD) and that patients with subclinical RBD did not have significantly reduced 123I-MIBG uptake. Moreover, among the studied variables, the existence of RBD symptoms alone was associated with reduced MIBG uptake among PD patients. PD patients with clinical RBD might suffer from a wider a-synuclein pathology, including reduced cardiac sympathetic ganglia function as reflected by a lowered 123I-MIBG uptake. In another recent report, Kashihara et al. showed that cardiac 123I-MIBG uptake was more markedly reduced in patients with idiopathic RBD (iRBD) than in those with early stage PD [ [2] Kashihara K. Imamura T. Shinya T. Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson’s disease. Parkinsonism Relat Disord. 2010; 16: 252-255 Abstract Full Text Full Text PDF PubMed Scopus (87) Google Scholar ]. IRBD may not necessarily be a prodromal condition of PD with respect to cardiac 123I-MIBG uptake results. Lesions responsible for RBD are located or linked more closely to the lesion responsible for decreased 123I-MIBG uptake than are lesions in patients with PD. Authors’ reply to the comments of Miyamoto et al. regarding “Cardiac 123I-MIBG accumulation in Parkinson’s disease differs in association with REM sleep behavior disorder”Parkinsonism & Related DisordersVol. 17Issue 8PreviewWe thank Dr. Miyamoto and coworkers for their interest in our article and for their comments, and we would like to respond as follows. Full-Text PDF" @default.
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• W2022164975 title "Cardiac 123I-MIBG accumulation in Parkinson’s disease differs in association with REM sleep behavior disorder" @default.
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