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• W2022167014 startingPage "1097" @default.
• W2022167014 abstract "Chylomicrons carry dietary fats in the bloodstream for storage in body tissues, and thus play an important role in obesity. The 2-step chylomicron metabolism consists of lipolysis by lipoprotein lipase (LPL) on vessel walls and hepatic uptake of triglyceride-depleted remnants. A triglyceride-rich emulsion that mimics chylomicrons, labeled with [9,10-3H]glycerol-trioleate (TG) and [1-14C] cholesteryl-oleate (CE) was intravenously injected into 14 obese women with body mass index between 30 and 40 kg/m2 (age, 30 to 40 years), before and after a 2-month energy-restricted diet and into non-obese controls for determination of radioactive lipid plasma kinetics. TG kinetics evaluates lipolysis, whereas CE kinetics evaluates remnant removal. The emulsion TG fractional clearance rate (FCR, in min[minus ]1) was similar in obese women and their controls (0.126 [plusmn] 0.065; controls, 0.111 [plusmn] 0.031), but the CE-FCR was pronouncedly reduced in the obese subjects (0.028 [plusmn] 0.014; controls, 0.070 [plusmn] 0.009 min[minus ]1; P [lt ] .0001). After the energy-restricted diet, TG-FCR was reduced in the obese women (0.075 [plusmn] 0.044 min[minus ]1; P [lt ] .05), but CE-FCR was unchanged (0.032 [plusmn] 0.025 min[minus ]1). Therefore, the lipolysis of the chylomicron-like emulsion is normal in obese women, but remnant removal from the plasma is diminished. After active weight loss by an energy-restricted diet, the remnant removal was unchanged but lipolysis was diminished, possibly due to adaptative changes in LPL activity." @default.
• W2022167014 created "2016-06-24" @default.
• W2022167014 creator A5006301452 @default.
• W2022167014 creator A5058308987 @default.
• W2022167014 date "2002-09-01" @default.
• W2022167014 modified "2023-10-14" @default.
• W2022167014 title "Plasma kinetics of a chylomicron-like emulsion in normolipidemic obese women after a short-period weight loss by energy-restricted diet" @default.
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• W2022167014 doi "https://doi.org/10.1053/meta.2002.34698" @default.
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