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• W2022168313 endingPage "2072" @default.
• W2022168313 startingPage "2068" @default.
• W2022168313 abstract "Neuropeptide Y is a 36-amino acid peptide that is abundant throughout the mammalian nervous system. It belongs to the same family of carboxyl-terminally amidated peptides as pancreatic polypeptide and peptide YY. We describe here the gene encoding the rat neuropeptide Y precursor. The gene spans 7.2 kilobase pairs and contains four exons. The exon organization is identical to the pancreatic polypeptide gene, although the amino acid sequences of the neuropeptide Y and pancreatic polypeptide precursors differ extensively. The predicted amino acid sequence of mature rat neuropeptide Y is identical to the human sequence. Also the sequence of the 30-amino acid carboxyl-terminal peptide of preproneuropeptide Y is highly conserved, which suggests that it is functionally important. Two neuropeptide Y alleles were found to differ at nine positions in 2.5 kilobase pairs at the 5' portion of the gene. No exon difference was found. One nucleotide substitution close to the gene promoter may influence the regulation of expression. Neuropeptide Y mRNA was found in all rat brain subregions tested, which shows that neuropeptide Y is synthesized throughout the brain. Developmentally, mRNA was detected in the rat brain as early as embryonic day 16 and increased rapidly to adult levels. The level of neuropeptide Y mRNA was also studied in several rat peripheral organs. Unexpectedly high levels were observed in heart and spleen. This mRNA may be synthesized in intrinsic ganglia and non-neuronal cells, respectively." @default.
• W2022168313 created "2016-06-24" @default.
• W2022168313 creator A5017313466 @default.
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• W2022168313 creator A5061245649 @default.
• W2022168313 date "1987-04-01" @default.
• W2022168313 modified "2023-10-08" @default.
• W2022168313 title "Structure and expression of the rat neuropeptide Y gene." @default.
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• W2022168313 doi "https://doi.org/10.1073/pnas.84.7.2068" @default.
• W2022168313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/304586" @default.
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• W2022168313 hasPublicationYear "1987" @default.
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