FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022169749> ?p ?o ?g. }

• W2022169749 endingPage "946" @default.
• W2022169749 startingPage "939" @default.
• W2022169749 abstract "Iron chelates of inositol 1,2,3-trisphosphate and inositol 1,2,3,6-tetrakisphosphate lacked free coordination sites and prevented the iron-catalyzed oxidation of ascorbic acid and peroxidation of arachidonic acid. In contrast, iron chelates of inositol 1,2,6-trisphosphate and inositol 1,2,5,6-tetrakisphosphate contained available coordination sites, permitted iron-catalyzed ascorbic acid oxidation, and enhanced arachidonic acid peroxidation. It was concluded that the 1,2,3-trisphosphate grouping of inositol hexakisphosphate was responsible for the inhibition of iron-catalyzed hydroxyl radical formation. The structure of the chelate with the phosphates in an axial-equatorial-axial configuration appeared to be the only possible inositol trisphosphate that could form bonds between six oxygen atoms and the six coordination sites on iron. Km values for cleavage by Escherichia coli alkaline phosphatase were as follows: inositol 1,2,3-trisphosphate, 56 μM; inositol 1,2,6-trisphosphate, 35 μM; inositol 1,2,3,6-tetrakisphosphate, 139 μM; and inositol 1,2,5,6-tetrakisphosphate, 100 μM. The initial hydrolysis rates of 200 μM solutions of the latter three isomers by E. coli alkaline phosphatase were not affected by an equimolar concentration of iron, whereas the rate for inositol 1,2,3-trisphosphate decreased in the presence of iron to 50% of the control. Therefore, the antioxidant potential of inositol 1,2,3-trisphosphate and inositol 1,2,3,6-tetrakisphosphate in cells and other biological systems may be fortified by the resistance of their iron chelates to enzymatic hydrolysis of the functional 1,2,3-trisphosphate array. Copyright © 1997 Elsevier Science Inc." @default.
• W2022169749 created "2016-06-24" @default.
• W2022169749 creator A5074300322 @default.
• W2022169749 creator A5080455496 @default.
• W2022169749 date "1997-01-01" @default.
• W2022169749 modified "2023-10-14" @default.
• W2022169749 title "Antioxidant functions of Inositol 1,2,3-trisphosphate and Inositol 1,2,3,6-tetrakisphosphate" @default.
• W2022169749 cites W138990427 @default.
• W2022169749 cites W1484360204 @default.
• W2022169749 cites W1502480849 @default.
• W2022169749 cites W1509513505 @default.
• W2022169749 cites W1543490555 @default.
• W2022169749 cites W1544609822 @default.
• W2022169749 cites W1546482094 @default.
• W2022169749 cites W1550426817 @default.
• W2022169749 cites W1561783467 @default.
• W2022169749 cites W1597258125 @default.
• W2022169749 cites W1621595817 @default.
• W2022169749 cites W1800914548 @default.
• W2022169749 cites W1861040413 @default.
• W2022169749 cites W1899701493 @default.
• W2022169749 cites W1911564316 @default.
• W2022169749 cites W194019980 @default.
• W2022169749 cites W1949684022 @default.
• W2022169749 cites W1978274366 @default.
• W2022169749 cites W1979644010 @default.
• W2022169749 cites W1981727920 @default.
• W2022169749 cites W1985594412 @default.
• W2022169749 cites W1988925337 @default.
• W2022169749 cites W1991695786 @default.
• W2022169749 cites W2001207936 @default.
• W2022169749 cites W2011497287 @default.
• W2022169749 cites W2015436906 @default.
• W2022169749 cites W2023518603 @default.
• W2022169749 cites W2024214998 @default.
• W2022169749 cites W2042127371 @default.
• W2022169749 cites W2043381365 @default.
• W2022169749 cites W2049595587 @default.
• W2022169749 cites W2052425836 @default.
• W2022169749 cites W2064034017 @default.
• W2022169749 cites W2064364009 @default.
• W2022169749 cites W2065289723 @default.
• W2022169749 cites W2074591873 @default.
• W2022169749 cites W2079899133 @default.
• W2022169749 cites W2080542488 @default.
• W2022169749 cites W2085235967 @default.
• W2022169749 cites W2089462522 @default.
• W2022169749 cites W2090096594 @default.
• W2022169749 cites W2095870639 @default.
• W2022169749 cites W2098860669 @default.
• W2022169749 cites W2114817053 @default.
• W2022169749 cites W2117315411 @default.
• W2022169749 cites W2122185256 @default.
• W2022169749 cites W2127764420 @default.
• W2022169749 cites W2136016121 @default.
• W2022169749 cites W2172120325 @default.
• W2022169749 cites W2328086619 @default.
• W2022169749 cites W2410670672 @default.
• W2022169749 cites W2952968832 @default.
• W2022169749 doi "https://doi.org/10.1016/s0891-5849(96)00342-5" @default.
• W2022169749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9034232" @default.
• W2022169749 hasPublicationYear "1997" @default.
• W2022169749 type Work @default.
• W2022169749 sameAs 2022169749 @default.
• W2022169749 citedByCount "79" @default.
• W2022169749 countsByYear W20221697492012 @default.
• W2022169749 countsByYear W20221697492013 @default.
• W2022169749 countsByYear W20221697492014 @default.
• W2022169749 countsByYear W20221697492015 @default.
• W2022169749 countsByYear W20221697492016 @default.
• W2022169749 countsByYear W20221697492017 @default.
• W2022169749 countsByYear W20221697492018 @default.
• W2022169749 countsByYear W20221697492019 @default.
• W2022169749 countsByYear W20221697492021 @default.
• W2022169749 countsByYear W20221697492022 @default.
• W2022169749 countsByYear W20221697492023 @default.
• W2022169749 crossrefType "journal-article" @default.
• W2022169749 hasAuthorship W2022169749A5074300322 @default.
• W2022169749 hasAuthorship W2022169749A5080455496 @default.
• W2022169749 hasConcept C170493617 @default.
• W2022169749 hasConcept C179104552 @default.
• W2022169749 hasConcept C185592680 @default.
• W2022169749 hasConcept C197404232 @default.
• W2022169749 hasConcept C2777427919 @default.
• W2022169749 hasConcept C2778004101 @default.
• W2022169749 hasConcept C2778618036 @default.
• W2022169749 hasConcept C2986274086 @default.
• W2022169749 hasConcept C31903555 @default.
• W2022169749 hasConcept C55493867 @default.
• W2022169749 hasConceptScore W2022169749C170493617 @default.
• W2022169749 hasConceptScore W2022169749C179104552 @default.
• W2022169749 hasConceptScore W2022169749C185592680 @default.
• W2022169749 hasConceptScore W2022169749C197404232 @default.
• W2022169749 hasConceptScore W2022169749C2777427919 @default.
• W2022169749 hasConceptScore W2022169749C2778004101 @default.
• W2022169749 hasConceptScore W2022169749C2778618036 @default.
• W2022169749 hasConceptScore W2022169749C2986274086 @default.
• W2022169749 hasConceptScore W2022169749C31903555 @default.

• next