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- W2022170432 abstract "Severity is an important characteristic of major depression (MD) and an 'episode specifier' in DSM-IV classifying depressive episodes as 'mild', 'moderate' or 'severe'. These severity subtypes rely on three different measures of severity: number of criteria symptoms, severity of the symptoms and degree of functional disability. No prior empirical study has evaluated the coherence and validity of the DSM-IV definition of severity of MD.In a sample of 1015 (518 males, 497 females) Caucasian twins from a population-based registry who met criteria for MD in the year prior to interview, factor analysis and logistic regression were conducted to examine the inter-relationships of the three severity measures and their associations with a wide range of potential validators including demographic factors, risk for future episodes, risk of MD in the co-twin, characteristics of the depressive episode, the pattern of co-morbidity, and personality traits.Correlations between the three severity measures were significant but moderate. Factor analysis indicated the existence of a general severity factor, but the factor was not highly coherent. The three severity measures showed differential predictive ability for most of the validators.Severity of MD as defined by the DSM-IV is a multifaceted and heterogeneous construct. The three proposed severity measures reflect partly overlapping but partly independent domains with differential validity as assessed by a wide range of clinical characteristics. Clinicians should probably use a combination of severity measures as proposed in DSM-IV rather than privileging one." @default.
- W2022170432 created "2016-06-24" @default.
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- W2022170432 date "2010-01-08" @default.
- W2022170432 modified "2023-09-27" @default.
- W2022170432 title "The DSM-IV definition of severity of major depression: inter-relationship and validity" @default.
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- W2022170432 doi "https://doi.org/10.1017/s0033291709992066" @default.
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