FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022170679> ?p ?o ?g. }

• W2022170679 endingPage "2247" @default.
• W2022170679 startingPage "2237" @default.
• W2022170679 abstract "Cyclo-oxygenase (COX)-2 selective inhibitors (coxibs) were designed to reduce the incidence of gastrointestinal (GI) adverse events (AEs) which occur with non-selective NSAIDs (ns-NSAIDs). Etoricoxib and lumiracoxib are regarded as second generation coxibs because of their higher COX-2 selectivity. There are three published pooled analyses relating to the GI tolerability of etoricoxib (60-120 mg/day) and lumiracoxib (200-400 mg/day) which used individual patient's data from studies sponsored by the manufacturers. We also reviewed new clinical trials published after the pooled analyses, to determine the global GI safety profiles of etoricoxib and lumiracoxib. We included discontinuations due to GI events, endoscopic ulcers, symptomatic ulcers, and ulcer complications. Current evidence suggests that etoricoxib and lumiracoxib have significantly more favorable GI profiles than ns-NSAIDs, and are similar to first generation coxibs with respect to GI safety. The most clinically important benefit of the coxibs is seen in the reduced rate of symptomatic ulcer and ulcer complications, which are still common in chronic NSAIDs users especially in high risk patients. In the largest GI outcome study of any coxib, TARGET, involving more than 18,000 patients, lumiracoxib was associated with a 79% reduction in ulcer complications in patients not taking aspirin. The differences between etoricoxib or lumiracoxib and ns-NSAIDs in relation to ulcer complications are apparent early during treatment and remain constant over time during the course of treatment; therefore, benefit of etoricoxib and lumiracoxib can be seen in patients with high GI ulcer complication risk who require NSAIDs from the beginning of use to throughout the prescription duration." @default.
• W2022170679 created "2016-06-24" @default.
• W2022170679 creator A5003596217 @default.
• W2022170679 creator A5059184078 @default.
• W2022170679 date "2007-08-01" @default.
• W2022170679 modified "2023-09-27" @default.
• W2022170679 title "Global Gastrointestinal Safety Profile of Etoricoxib and Lumiracoxib" @default.
• W2022170679 cites W1495262111 @default.
• W2022170679 cites W1558803517 @default.
• W2022170679 cites W1561747056 @default.
• W2022170679 cites W1587112446 @default.
• W2022170679 cites W1717393871 @default.
• W2022170679 cites W1902187490 @default.
• W2022170679 cites W1913488932 @default.
• W2022170679 cites W1953196589 @default.
• W2022170679 cites W1967276177 @default.
• W2022170679 cites W1968421482 @default.
• W2022170679 cites W1969798546 @default.
• W2022170679 cites W1972361929 @default.
• W2022170679 cites W1985247069 @default.
• W2022170679 cites W1986215651 @default.
• W2022170679 cites W1990213388 @default.
• W2022170679 cites W1993621419 @default.
• W2022170679 cites W1998283731 @default.
• W2022170679 cites W2003176154 @default.
• W2022170679 cites W2004418784 @default.
• W2022170679 cites W2006813311 @default.
• W2022170679 cites W2007061152 @default.
• W2022170679 cites W2011579224 @default.
• W2022170679 cites W2013166307 @default.
• W2022170679 cites W2013218243 @default.
• W2022170679 cites W2014785656 @default.
• W2022170679 cites W2017082074 @default.
• W2022170679 cites W2020563114 @default.
• W2022170679 cites W2023622543 @default.
• W2022170679 cites W2025838546 @default.
• W2022170679 cites W2027076841 @default.
• W2022170679 cites W2030321028 @default.
• W2022170679 cites W2044214724 @default.
• W2022170679 cites W2057685090 @default.
• W2022170679 cites W2057969209 @default.
• W2022170679 cites W2059057579 @default.
• W2022170679 cites W2060835590 @default.
• W2022170679 cites W2062772837 @default.
• W2022170679 cites W2069794978 @default.
• W2022170679 cites W2071263587 @default.
• W2022170679 cites W2073714032 @default.
• W2022170679 cites W2083325871 @default.
• W2022170679 cites W2087324295 @default.
• W2022170679 cites W2089412791 @default.
• W2022170679 cites W2093586224 @default.
• W2022170679 cites W2094278006 @default.
• W2022170679 cites W2104379105 @default.
• W2022170679 cites W2105627779 @default.
• W2022170679 cites W2106828783 @default.
• W2022170679 cites W2109156797 @default.
• W2022170679 cites W2117227343 @default.
• W2022170679 cites W2118840514 @default.
• W2022170679 cites W2124451844 @default.
• W2022170679 cites W2127889677 @default.
• W2022170679 cites W2128628109 @default.
• W2022170679 cites W2128738050 @default.
• W2022170679 cites W2128861006 @default.
• W2022170679 cites W2128865776 @default.
• W2022170679 cites W2133888386 @default.
• W2022170679 cites W2134330353 @default.
• W2022170679 cites W2137981468 @default.
• W2022170679 cites W2138361936 @default.
• W2022170679 cites W2138854915 @default.
• W2022170679 cites W2139781083 @default.
• W2022170679 cites W2146447031 @default.
• W2022170679 cites W2147490567 @default.
• W2022170679 cites W2158365407 @default.
• W2022170679 cites W2160685542 @default.
• W2022170679 cites W2163306078 @default.
• W2022170679 cites W2163756514 @default.
• W2022170679 cites W2164323898 @default.
• W2022170679 cites W2263874761 @default.
• W2022170679 cites W2330496155 @default.
• W2022170679 cites W2346641421 @default.
• W2022170679 cites W2420374579 @default.
• W2022170679 doi "https://doi.org/10.2174/138161207781368792" @default.
• W2022170679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17691997" @default.
• W2022170679 hasPublicationYear "2007" @default.
• W2022170679 type Work @default.
• W2022170679 sameAs 2022170679 @default.
• W2022170679 citedByCount "8" @default.
• W2022170679 countsByYear W20221706792012 @default.
• W2022170679 countsByYear W20221706792013 @default.
• W2022170679 countsByYear W20221706792014 @default.
• W2022170679 countsByYear W20221706792021 @default.
• W2022170679 countsByYear W20221706792023 @default.
• W2022170679 crossrefType "journal-article" @default.
• W2022170679 hasAuthorship W2022170679A5003596217 @default.
• W2022170679 hasAuthorship W2022170679A5059184078 @default.
• W2022170679 hasConcept C126322002 @default.
• W2022170679 hasConcept C197934379 @default.
• W2022170679 hasConcept C2776214540 @default.

• next