Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022172467> ?p ?o ?g. }
- W2022172467 endingPage "131" @default.
- W2022172467 startingPage "131" @default.
- W2022172467 abstract "Alzheimer's disease (AD) is the most common form of dementia in individuals over 65 years of age and is characterized by accumulation of beta-amyloid (Aβ) and tau. Both Aβ and tau alter synaptic plasticity, leading to synapse loss, neural network dysfunction, and eventually neuron loss. However, the exact mechanism by which these proteins cause neurodegeneration is still not clear. A growing body of evidence suggests perturbations in the glutamatergic tripartite synapse, comprised of a presynaptic terminal, a postsynaptic spine, and an astrocytic process, may underlie the pathogenic mechanisms of AD. Glutamate is the primary excitatory neurotransmitter in the brain and plays an important role in learning and memory, but alterations in glutamatergic signaling can lead to excitotoxicity. This review discusses the ways in which both beta-amyloid (Aβ) and tau act alone and in concert to perturb synaptic functioning of the tripartite synapse, including alterations in glutamate release, astrocytic uptake, and receptor signaling. Particular emphasis is given to the role of N-methyl-D-aspartate (NMDA) as a possible convergence point for Aβ and tau toxicity." @default.
- W2022172467 created "2016-06-24" @default.
- W2022172467 creator A5011499689 @default.
- W2022172467 creator A5016790931 @default.
- W2022172467 creator A5063814814 @default.
- W2022172467 creator A5064810621 @default.
- W2022172467 date "2015-01-01" @default.
- W2022172467 modified "2023-10-13" @default.
- W2022172467 title "The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology of Alzheimer’s Disease" @default.
- W2022172467 cites W1503789839 @default.
- W2022172467 cites W1513808048 @default.
- W2022172467 cites W1553519131 @default.
- W2022172467 cites W1557933310 @default.
- W2022172467 cites W1564717701 @default.
- W2022172467 cites W1570725062 @default.
- W2022172467 cites W1571617145 @default.
- W2022172467 cites W1577728810 @default.
- W2022172467 cites W1582986153 @default.
- W2022172467 cites W1584834830 @default.
- W2022172467 cites W1592375995 @default.
- W2022172467 cites W1595726542 @default.
- W2022172467 cites W1599662080 @default.
- W2022172467 cites W1600525795 @default.
- W2022172467 cites W1644388421 @default.
- W2022172467 cites W1802786708 @default.
- W2022172467 cites W1900227502 @default.
- W2022172467 cites W1916850619 @default.
- W2022172467 cites W1945680072 @default.
- W2022172467 cites W1957958801 @default.
- W2022172467 cites W1964049915 @default.
- W2022172467 cites W1965351558 @default.
- W2022172467 cites W1965377078 @default.
- W2022172467 cites W1965902234 @default.
- W2022172467 cites W1966556202 @default.
- W2022172467 cites W1967113275 @default.
- W2022172467 cites W1967794260 @default.
- W2022172467 cites W1968553823 @default.
- W2022172467 cites W1968937229 @default.
- W2022172467 cites W1969317335 @default.
- W2022172467 cites W1969400861 @default.
- W2022172467 cites W1970796584 @default.
- W2022172467 cites W1972183007 @default.
- W2022172467 cites W1972188596 @default.
- W2022172467 cites W1973417580 @default.
- W2022172467 cites W1974720828 @default.
- W2022172467 cites W1974903553 @default.
- W2022172467 cites W1979889191 @default.
- W2022172467 cites W1980189512 @default.
- W2022172467 cites W1980750700 @default.
- W2022172467 cites W1982373527 @default.
- W2022172467 cites W1983350404 @default.
- W2022172467 cites W1983611639 @default.
- W2022172467 cites W1984089779 @default.
- W2022172467 cites W1984924722 @default.
- W2022172467 cites W1988718039 @default.
- W2022172467 cites W1990625157 @default.
- W2022172467 cites W1990752558 @default.
- W2022172467 cites W1991449336 @default.
- W2022172467 cites W1992176243 @default.
- W2022172467 cites W1993465897 @default.
- W2022172467 cites W1995906542 @default.
- W2022172467 cites W1997126666 @default.
- W2022172467 cites W1997890299 @default.
- W2022172467 cites W1998347917 @default.
- W2022172467 cites W1999782689 @default.
- W2022172467 cites W2000300989 @default.
- W2022172467 cites W2000304313 @default.
- W2022172467 cites W2000863257 @default.
- W2022172467 cites W2000931014 @default.
- W2022172467 cites W2001261203 @default.
- W2022172467 cites W2001900724 @default.
- W2022172467 cites W2005816735 @default.
- W2022172467 cites W2006569015 @default.
- W2022172467 cites W2007387168 @default.
- W2022172467 cites W2007495000 @default.
- W2022172467 cites W2009782005 @default.
- W2022172467 cites W2009942449 @default.
- W2022172467 cites W2010476270 @default.
- W2022172467 cites W2010747985 @default.
- W2022172467 cites W2010926499 @default.
- W2022172467 cites W2012365932 @default.
- W2022172467 cites W2013067874 @default.
- W2022172467 cites W2014593683 @default.
- W2022172467 cites W2016365511 @default.
- W2022172467 cites W2017389079 @default.
- W2022172467 cites W2017523469 @default.
- W2022172467 cites W2018157246 @default.
- W2022172467 cites W2019347164 @default.
- W2022172467 cites W2021671423 @default.
- W2022172467 cites W2022532556 @default.
- W2022172467 cites W2023986336 @default.
- W2022172467 cites W2024989540 @default.
- W2022172467 cites W2025247587 @default.
- W2022172467 cites W2027275070 @default.
- W2022172467 cites W2027550281 @default.
- W2022172467 cites W2028174194 @default.
- W2022172467 cites W2031102482 @default.
- W2022172467 cites W2032089431 @default.