FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022173241> ?p ?o ?g. }

• W2022173241 endingPage "1104" @default.
• W2022173241 startingPage "1104" @default.
• W2022173241 abstract "To study the individual effects of glucocorticoid (GC) therapy on the state of immune activation in patient serum.We developed a novel assay in which the effect of corticosteroid-treated patient serum on healthy donor peripheral blood mononuclear cells (target cells) was studied, with a panel of markers for effector [interferon (IFN)gamma and interleukin (IL)-5] and regulatory T cells (FOXP3 and glucocorticoid-induced tumor necrosis factor receptor, GITR). The study group comprised 19 children with inflammatory bowel disease. The individual effect of patient serum on target cells was analyzed prior to GC therapy and 2 wk later.The effect of GC therapy mediated by patient serum was seen as a decrease in the target cells expression of regulatory T-cell-related markers GITR (median suppression 24%, range of suppression 1%-63%, in 2 cases increase of 6% and 77%, P < 0.01 for mitogen-activated target cells) and FOXP3 (median suppression 33%, range of suppression 0%-79%, in one case an increase of 173%, P < 0.05 for resting cells), and secretion of IFNgamma [from a mean of 87 700 pg/mL (SD 33 900 pg/mL) to 60 900 pg/mL (SD 44 200 pg/mL) in mitogen-activated target cells, 13 of the cases showed a decrease, P < 0.01]. The total or weight-related prednisolone dose did not correlate with the patient-serum-induced changes in the target cell markers.GC response could be monitored at an individual level by studying the effect of patient serum on signaling pathways of target immune cells." @default.
• W2022173241 created "2016-06-24" @default.
• W2022173241 creator A5048842642 @default.
• W2022173241 date "2010-01-01" @default.
• W2022173241 modified "2023-09-25" @default.
• W2022173241 title "New means to monitor the effect of glucocorticoid therapy in children" @default.
• W2022173241 cites W1922735013 @default.
• W2022173241 cites W1964704603 @default.
• W2022173241 cites W1965073345 @default.
• W2022173241 cites W1975801129 @default.
• W2022173241 cites W1979948289 @default.
• W2022173241 cites W1981722357 @default.
• W2022173241 cites W1989565558 @default.
• W2022173241 cites W1991600170 @default.
• W2022173241 cites W2010372358 @default.
• W2022173241 cites W2011756150 @default.
• W2022173241 cites W2017197964 @default.
• W2022173241 cites W2021886057 @default.
• W2022173241 cites W2043382313 @default.
• W2022173241 cites W2045904496 @default.
• W2022173241 cites W2051677588 @default.
• W2022173241 cites W2065637841 @default.
• W2022173241 cites W2074432289 @default.
• W2022173241 cites W2080610328 @default.
• W2022173241 cites W2088487119 @default.
• W2022173241 cites W2093502624 @default.
• W2022173241 cites W2101827245 @default.
• W2022173241 cites W2110244387 @default.
• W2022173241 cites W2150691073 @default.
• W2022173241 cites W2154117979 @default.
• W2022173241 cites W2171789845 @default.
• W2022173241 cites W2181889251 @default.
• W2022173241 cites W2412830993 @default.
• W2022173241 doi "https://doi.org/10.3748/wjg.v16.i9.1104" @default.
• W2022173241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2835787" @default.
• W2022173241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20205281" @default.
• W2022173241 hasPublicationYear "2010" @default.
• W2022173241 type Work @default.
• W2022173241 sameAs 2022173241 @default.
• W2022173241 citedByCount "10" @default.
• W2022173241 countsByYear W20221732412012 @default.
• W2022173241 crossrefType "journal-article" @default.
• W2022173241 hasAuthorship W2022173241A5048842642 @default.
• W2022173241 hasBestOaLocation W20221732411 @default.
• W2022173241 hasConcept C126322002 @default.
• W2022173241 hasConcept C134018914 @default.
• W2022173241 hasConcept C137061746 @default.
• W2022173241 hasConcept C17991360 @default.
• W2022173241 hasConcept C185592680 @default.
• W2022173241 hasConcept C202751555 @default.
• W2022173241 hasConcept C203014093 @default.
• W2022173241 hasConcept C2776715498 @default.
• W2022173241 hasConcept C2776804153 @default.
• W2022173241 hasConcept C2778690821 @default.
• W2022173241 hasConcept C2779727006 @default.
• W2022173241 hasConcept C2780841215 @default.
• W2022173241 hasConcept C55493867 @default.
• W2022173241 hasConcept C59493245 @default.
• W2022173241 hasConcept C71924100 @default.
• W2022173241 hasConcept C8891405 @default.
• W2022173241 hasConceptScore W2022173241C126322002 @default.
• W2022173241 hasConceptScore W2022173241C134018914 @default.
• W2022173241 hasConceptScore W2022173241C137061746 @default.
• W2022173241 hasConceptScore W2022173241C17991360 @default.
• W2022173241 hasConceptScore W2022173241C185592680 @default.
• W2022173241 hasConceptScore W2022173241C202751555 @default.
• W2022173241 hasConceptScore W2022173241C203014093 @default.
• W2022173241 hasConceptScore W2022173241C2776715498 @default.
• W2022173241 hasConceptScore W2022173241C2776804153 @default.
• W2022173241 hasConceptScore W2022173241C2778690821 @default.
• W2022173241 hasConceptScore W2022173241C2779727006 @default.
• W2022173241 hasConceptScore W2022173241C2780841215 @default.
• W2022173241 hasConceptScore W2022173241C55493867 @default.
• W2022173241 hasConceptScore W2022173241C59493245 @default.
• W2022173241 hasConceptScore W2022173241C71924100 @default.
• W2022173241 hasConceptScore W2022173241C8891405 @default.
• W2022173241 hasIssue "9" @default.
• W2022173241 hasLocation W20221732411 @default.
• W2022173241 hasLocation W20221732412 @default.
• W2022173241 hasLocation W20221732413 @default.
• W2022173241 hasLocation W20221732414 @default.
• W2022173241 hasLocation W20221732415 @default.
• W2022173241 hasOpenAccess W2022173241 @default.
• W2022173241 hasPrimaryLocation W20221732411 @default.
• W2022173241 hasRelatedWork W1975968177 @default.
• W2022173241 hasRelatedWork W2034583712 @default.
• W2022173241 hasRelatedWork W2066225521 @default.
• W2022173241 hasRelatedWork W2071337848 @default.
• W2022173241 hasRelatedWork W2092107317 @default.
• W2022173241 hasRelatedWork W2109154705 @default.
• W2022173241 hasRelatedWork W2170009353 @default.
• W2022173241 hasRelatedWork W2276893008 @default.
• W2022173241 hasRelatedWork W2277004805 @default.
• W2022173241 hasRelatedWork W4232773839 @default.
• W2022173241 hasVolume "16" @default.
• W2022173241 isParatext "false" @default.
• W2022173241 isRetracted "false" @default.
• W2022173241 magId "2022173241" @default.

• next