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• W2022175152 abstract "Protein kinase CK2 is involved in a broad range of physiological events. 3,8-dibromo-7-hydroxy-4-methylchromen-2-one (DBC) analogues show favorable inhibitory activity targeting CK2α. Two methods were used to build 3D-QSAR models for DBC derivatives. The ligand-based (LB) studies were performed based on the lower energy conformations employing atom fit alignment rule. The receptor-based (RB) models were also derived using bioactive conformations. Contour maps of RB CoMSIA model (q2 = 0.694, r2 = 0.916, N (no. of components) = 7, r2pred = 0.87) including the steric, electronic, hydrophobic and hydrogen bond acceptor fields were employed to explain factors affecting activities of inhibitors. The good consistency between the contour maps and the properties of CK2α amino acids provide useful hints for new inhibitors design." @default.
• W2022175152 created "2016-06-24" @default.
• W2022175152 creator A5039088967 @default.
• W2022175152 creator A5042467158 @default.
• W2022175152 date "2010-01-01" @default.
• W2022175152 modified "2023-10-04" @default.
• W2022175152 title "Docking and 3D-QSAR studies of 7-hydroxycoumarin derivatives as CK2 inhibitors" @default.
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• W2022175152 doi "https://doi.org/10.1016/j.ejmech.2009.10.011" @default.
• W2022175152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19879674" @default.
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