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- W2022175314 abstract "Objective: To investigate serum inflammatory factors in patients with idiopathic choroidal vascularization (CNV), including vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNFα), Interleukin1-beta (IL1-β), IgG, IgA, IgM, IgE, 50% hemolytic unit of complement (CH50), complement C3, complement C4 and C reactive protein (CRP).Methods: 21 patients and 20 normal individuals were recruited. They received comprehensive ophthalmic examinations. Serous concentrations of VEGF, TNFα, IL1-β were assayed by ELISA, and the concentrations of other serum factor were assayed by immunonephelometry.Results: The mean serum VEGF level in the CNV group was significantly greater than that in the control group (p=0.025). The median level of IgE in the CNV group was significantly lower than that in the control group (p=0.006). Statistical analysis revealed no significant difference in the levels of TNFα, IL1-β, IgG, IgA, IgM, CH50, C3, C4 or CRP between the two groups.Conclusion: The possible roles of these factors and mechanisms of idiopathic CNV formation were analyzed. Serum VEGF and IgE levels may play an important role in the formation of idiopathic CNV." @default.
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- W2022175314 date "2010-07-28" @default.
- W2022175314 modified "2023-09-26" @default.
- W2022175314 title "Serum Inflammatory Factors in Patients with Idiopathic Choroidal Neovascularization" @default.
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- W2022175314 doi "https://doi.org/10.3109/09273948.2010.483315" @default.
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