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- W2022176532 abstract "Background: The Tigecycline In-Vitro Surveillance in Taiwan (TIST), initiated in 2006, is a nationwide surveillance program designed to monitor longitudinally the in vitro activities of tigecycline against commonly encountered resistant bacteria in Taiwan. This study aims to determine the in vitro activities of tigecycline against clinical isolates of Acinetobacter baumannii in Taiwan. Methods: A total of 393 isolates of A. baumannii were collected from various sources of patients treated at 20 teaching hospitals. Minimum inhibitory concentrations (MICs) for tigecycline were determined by the broth microdilution methods according the guidelines described by Clinical and Laboratory Standards Institute (CLSI). The results were interpreted by the MIC criteria provided by U.S. FDA tigecycline susceptibility breakpoints listed for Enterobacteriaceae (S, ≤2 μg/mL; I, 4 μg/mL; R, ≥8 μg/mL). All isolates were also examined for susceptibility to other 11 antimicrobial agents using the disk diffusion method and the results were interpreted by the CLSI criteria. Results: Of these A. baumannii isolates, 81.7% were susceptible to tigecycline by the broth dilution method. Susceptibility rates of tigecycline to several resistant phenotypes determined by the disk diffusion method are shown below. Conclusion: Tigecycline exhibited good in vitro activities (>70%) against Taiwanese A. baumannii isolates, including various resistant phenotypes." @default.
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- W2022176532 date "2008-12-01" @default.
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- W2022176532 title "Nationwide Surveillance of in vitro Activities of Tigecycline against Clinical Isolates of Acinetobacter baumannii in Taiwan" @default.
- W2022176532 doi "https://doi.org/10.1016/j.ijid.2008.05.290" @default.
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