Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022176861> ?p ?o ?g. }
- W2022176861 endingPage "780" @default.
- W2022176861 startingPage "773" @default.
- W2022176861 abstract "We used vertical growth phase (VGP) human VMM5 melanoma cells to ask whether the tumor microenvironment could induce matrix metalloproteinase-1 (MMP-1) in vivo, and whether this induction correlated with metastasis. We isolated two clones from parental VMM5 cells: a low MMP-1 producing clone (C4) and high producing clone (C9). When these clones were injected orthotopically (intradermally) into nude mice, both were equally tumorigenic and produced equivalent and abundant amounts of MMP-1. However, the tumors from the C4 clones displayed different growth kinetics and distinct profiles of gene expression from the C9 population. The C4 tumors, which had low MMP-1 levels in vitro, appeared to rely on growth factors and cytokines in the microenvironment to increase MMP-1 expression in vivo, while MMP-1 levels remained constant in the C9 tumors. C9 cells, but not C4 cells, grew as spheres in culture and expressed higher levels of JARID 1B, a marker associated with melanoma initiating cells. We conclude that VMM5 melanoma cells exhibit striking intra-tumor heterogeneity, and that the tumorigenicity of these clones is driven by different molecular pathways. Our data suggest that there are multiple mechanisms for melanoma progression within a tumor, which may require different therapeutic strategies." @default.
- W2022176861 created "2016-06-24" @default.
- W2022176861 creator A5006401578 @default.
- W2022176861 creator A5031193075 @default.
- W2022176861 creator A5034401601 @default.
- W2022176861 creator A5056215691 @default.
- W2022176861 creator A5087654744 @default.
- W2022176861 date "2012-12-20" @default.
- W2022176861 modified "2023-09-27" @default.
- W2022176861 title "Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma" @default.
- W2022176861 cites W1509507060 @default.
- W2022176861 cites W1525484196 @default.
- W2022176861 cites W1582730540 @default.
- W2022176861 cites W1590243782 @default.
- W2022176861 cites W1733656319 @default.
- W2022176861 cites W190590421 @default.
- W2022176861 cites W1924003041 @default.
- W2022176861 cites W1967989242 @default.
- W2022176861 cites W1970597252 @default.
- W2022176861 cites W2008878539 @default.
- W2022176861 cites W2016316780 @default.
- W2022176861 cites W2017903142 @default.
- W2022176861 cites W2023101194 @default.
- W2022176861 cites W2030207261 @default.
- W2022176861 cites W2033290644 @default.
- W2022176861 cites W2042082129 @default.
- W2022176861 cites W2049474645 @default.
- W2022176861 cites W2052510737 @default.
- W2022176861 cites W2053896971 @default.
- W2022176861 cites W2056216570 @default.
- W2022176861 cites W2064505857 @default.
- W2022176861 cites W2072569544 @default.
- W2022176861 cites W2077625736 @default.
- W2022176861 cites W2080429622 @default.
- W2022176861 cites W2083403388 @default.
- W2022176861 cites W2089166857 @default.
- W2022176861 cites W2096788030 @default.
- W2022176861 cites W2104666893 @default.
- W2022176861 cites W2105986003 @default.
- W2022176861 cites W2124618015 @default.
- W2022176861 cites W2136421130 @default.
- W2022176861 cites W2143028729 @default.
- W2022176861 cites W2146113634 @default.
- W2022176861 cites W2149086763 @default.
- W2022176861 cites W2149683780 @default.
- W2022176861 cites W2153814729 @default.
- W2022176861 doi "https://doi.org/10.1002/jcp.24225" @default.
- W2022176861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3864099" @default.
- W2022176861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23001823" @default.
- W2022176861 hasPublicationYear "2012" @default.
- W2022176861 type Work @default.
- W2022176861 sameAs 2022176861 @default.
- W2022176861 citedByCount "12" @default.
- W2022176861 countsByYear W20221768612013 @default.
- W2022176861 countsByYear W20221768612014 @default.
- W2022176861 countsByYear W20221768612015 @default.
- W2022176861 countsByYear W20221768612016 @default.
- W2022176861 countsByYear W20221768612017 @default.
- W2022176861 countsByYear W20221768612019 @default.
- W2022176861 countsByYear W20221768612020 @default.
- W2022176861 crossrefType "journal-article" @default.
- W2022176861 hasAuthorship W2022176861A5006401578 @default.
- W2022176861 hasAuthorship W2022176861A5031193075 @default.
- W2022176861 hasAuthorship W2022176861A5034401601 @default.
- W2022176861 hasAuthorship W2022176861A5056215691 @default.
- W2022176861 hasAuthorship W2022176861A5087654744 @default.
- W2022176861 hasBestOaLocation W20221768612 @default.
- W2022176861 hasConcept C104317684 @default.
- W2022176861 hasConcept C109523444 @default.
- W2022176861 hasConcept C121608353 @default.
- W2022176861 hasConcept C202751555 @default.
- W2022176861 hasConcept C203014093 @default.
- W2022176861 hasConcept C207001950 @default.
- W2022176861 hasConcept C2776107976 @default.
- W2022176861 hasConcept C2777658100 @default.
- W2022176861 hasConcept C2779013556 @default.
- W2022176861 hasConcept C2779256057 @default.
- W2022176861 hasConcept C2908647359 @default.
- W2022176861 hasConcept C3020616263 @default.
- W2022176861 hasConcept C502942594 @default.
- W2022176861 hasConcept C54355233 @default.
- W2022176861 hasConcept C71924100 @default.
- W2022176861 hasConcept C81089528 @default.
- W2022176861 hasConcept C81885089 @default.
- W2022176861 hasConcept C86803240 @default.
- W2022176861 hasConcept C99454951 @default.
- W2022176861 hasConceptScore W2022176861C104317684 @default.
- W2022176861 hasConceptScore W2022176861C109523444 @default.
- W2022176861 hasConceptScore W2022176861C121608353 @default.
- W2022176861 hasConceptScore W2022176861C202751555 @default.
- W2022176861 hasConceptScore W2022176861C203014093 @default.
- W2022176861 hasConceptScore W2022176861C207001950 @default.
- W2022176861 hasConceptScore W2022176861C2776107976 @default.
- W2022176861 hasConceptScore W2022176861C2777658100 @default.
- W2022176861 hasConceptScore W2022176861C2779013556 @default.
- W2022176861 hasConceptScore W2022176861C2779256057 @default.
- W2022176861 hasConceptScore W2022176861C2908647359 @default.
- W2022176861 hasConceptScore W2022176861C3020616263 @default.