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- W2022177360 abstract "The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail." @default.
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- W2022177360 date "2004-02-01" @default.
- W2022177360 modified "2023-09-25" @default.
- W2022177360 title "Identification of a region within SEL1L protein required for tumour growth inhibition" @default.
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- W2022177360 doi "https://doi.org/10.1016/j.gene.2003.10.021" @default.
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