Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022177664> ?p ?o ?g. }
- W2022177664 endingPage "1230" @default.
- W2022177664 startingPage "1224" @default.
- W2022177664 abstract "BackgroundLead is an environmental pollutant that causes acute and chronic toxicity. Surveys have related mean blood lead concentrations to exogenous sources, including industrial activity, use of lead-based paints, or traffic density. However, there has been little investigation of individual differences in lead absorption, distribution, or toxicity, or of genetic causes of such variation.ObjectivesWe assessed the genetic contribution to variation in blood lead concentration in adults and conducted a preliminary search for genes producing such variation.MethodsErythrocyte lead concentration was measured by inductively coupled plasma mass spectrometry in venous blood samples from 2,926 Australian adult male and female twins. Mean lead concentrations were compared by place of residence, social class and education, and by the subjects’ age, sex, alcohol intake, smoking habits, iron status, and HFE genotype.ResultsAfter adjustment for these covariates, there was strong evidence of genetic effects but not for shared environmental effects persisting into adult life. Linkage analysis showed suggestive evidence (logarithm of odds = 2.63, genome-wide p = 0.170) for a quantitative trait locus affecting blood lead values on chromosome 3 with the linkage peak close to SLC4A7, a gene whose product affects lead transport.ConclusionsWe conclude that genetic variation plays a significant role in determining lead absorption, lead distribution within the body, or both." @default.
- W2022177664 created "2016-06-24" @default.
- W2022177664 creator A5012652688 @default.
- W2022177664 creator A5025708492 @default.
- W2022177664 creator A5027640245 @default.
- W2022177664 creator A5027979950 @default.
- W2022177664 creator A5031179214 @default.
- W2022177664 creator A5031622757 @default.
- W2022177664 creator A5042130650 @default.
- W2022177664 creator A5043097777 @default.
- W2022177664 creator A5064749062 @default.
- W2022177664 creator A5074490470 @default.
- W2022177664 creator A5075624440 @default.
- W2022177664 date "2007-08-01" @default.
- W2022177664 modified "2023-10-15" @default.
- W2022177664 title "Evidence of Genetic Effects on Blood Lead Concentration" @default.
- W2022177664 cites W153354062 @default.
- W2022177664 cites W1903575303 @default.
- W2022177664 cites W1971998517 @default.
- W2022177664 cites W1972005427 @default.
- W2022177664 cites W1972478507 @default.
- W2022177664 cites W1976741643 @default.
- W2022177664 cites W1986073045 @default.
- W2022177664 cites W1994203390 @default.
- W2022177664 cites W2003953294 @default.
- W2022177664 cites W2006215146 @default.
- W2022177664 cites W2014549922 @default.
- W2022177664 cites W2016739844 @default.
- W2022177664 cites W2039042492 @default.
- W2022177664 cites W2059826926 @default.
- W2022177664 cites W2064885200 @default.
- W2022177664 cites W2066641433 @default.
- W2022177664 cites W2072073525 @default.
- W2022177664 cites W2081748307 @default.
- W2022177664 cites W2092250899 @default.
- W2022177664 cites W2094044679 @default.
- W2022177664 cites W2096624763 @default.
- W2022177664 cites W2097293856 @default.
- W2022177664 cites W2105306382 @default.
- W2022177664 cites W2107029880 @default.
- W2022177664 cites W2107871825 @default.
- W2022177664 cites W2116406442 @default.
- W2022177664 cites W2118094114 @default.
- W2022177664 cites W2122457010 @default.
- W2022177664 cites W2123078738 @default.
- W2022177664 cites W2127334295 @default.
- W2022177664 cites W2135040692 @default.
- W2022177664 cites W2135234710 @default.
- W2022177664 cites W2135405351 @default.
- W2022177664 cites W2140055726 @default.
- W2022177664 cites W2146334297 @default.
- W2022177664 cites W2150754072 @default.
- W2022177664 cites W2154953206 @default.
- W2022177664 cites W2157211482 @default.
- W2022177664 cites W2158489053 @default.
- W2022177664 cites W2163379992 @default.
- W2022177664 cites W2417289191 @default.
- W2022177664 cites W2428222999 @default.
- W2022177664 cites W4232336951 @default.
- W2022177664 cites W4233015392 @default.
- W2022177664 cites W4235425209 @default.
- W2022177664 cites W4242222465 @default.
- W2022177664 cites W4246320698 @default.
- W2022177664 cites W4320300838 @default.
- W2022177664 cites W96717503 @default.
- W2022177664 doi "https://doi.org/10.1289/ehp.8847" @default.
- W2022177664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1940084" @default.
- W2022177664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17687451" @default.
- W2022177664 hasPublicationYear "2007" @default.
- W2022177664 type Work @default.
- W2022177664 sameAs 2022177664 @default.
- W2022177664 citedByCount "35" @default.
- W2022177664 countsByYear W20221776642013 @default.
- W2022177664 countsByYear W20221776642014 @default.
- W2022177664 countsByYear W20221776642015 @default.
- W2022177664 countsByYear W20221776642016 @default.
- W2022177664 countsByYear W20221776642017 @default.
- W2022177664 countsByYear W20221776642018 @default.
- W2022177664 countsByYear W20221776642019 @default.
- W2022177664 countsByYear W20221776642021 @default.
- W2022177664 countsByYear W20221776642022 @default.
- W2022177664 countsByYear W20221776642023 @default.
- W2022177664 crossrefType "journal-article" @default.
- W2022177664 hasAuthorship W2022177664A5012652688 @default.
- W2022177664 hasAuthorship W2022177664A5025708492 @default.
- W2022177664 hasAuthorship W2022177664A5027640245 @default.
- W2022177664 hasAuthorship W2022177664A5027979950 @default.
- W2022177664 hasAuthorship W2022177664A5031179214 @default.
- W2022177664 hasAuthorship W2022177664A5031622757 @default.
- W2022177664 hasAuthorship W2022177664A5042130650 @default.
- W2022177664 hasAuthorship W2022177664A5043097777 @default.
- W2022177664 hasAuthorship W2022177664A5064749062 @default.
- W2022177664 hasAuthorship W2022177664A5074490470 @default.
- W2022177664 hasAuthorship W2022177664A5075624440 @default.
- W2022177664 hasBestOaLocation W20221776641 @default.
- W2022177664 hasConcept C104317684 @default.
- W2022177664 hasConcept C118552586 @default.
- W2022177664 hasConcept C126322002 @default.