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- W2022178194 abstract "Purpose Vascular 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) uptake has been suggested as a means of identifying metabolically active atheroma, whereas vascular calcification is accepted as an indicator of atherosclerosis. This investigation describes the frequency and stability of 18F-FDG uptake and vascular calcification in the thoracic aorta on serial 18F-FDG positron emission tomography/computed tomography (PET/CT) studies and correlates the findings with clinical data and risk factors for cardiovascular disease (CVD). Materials and Methods Serial 18F-FDG-PET/CT scans of 100 cancer patients who had at least 2 PET/CT studies were reviewed. Sites of aortic 18F-FDG uptake and calcifications were identified. Results were compared to assess the frequency and stability of the vascular findings and their correlation with clinical data. Results 18F-FDG aortic uptake was seen in 70% of the patients on the initial scan and changed on the second scan in 55% of the patients. Calcifications were often seen in patients with 18F-FDG uptake, but calcification and 18F-FDG uptake were present at the same site in only 2 cases. Both calcification and 18F-FDG uptake correlated with age. Patients with diabetes, hypertension, hyperlipidemia, or a history of CVD had significantly more calcifications. No correlation was seen between 18F-FDG uptake and calcification stability and the interval between scans, age, risk factors, or history of CVD. Conclusions 18F-FDG vascular uptake was common on PET/CT and correlated with vascular calcifications, although the specific sites rarely overlapped. Calcifications were stable over time, but 18F-FDG uptake changed in more than half of the patients, supporting the postulate that inflammation in atheroma is a waxing and waning inflammatory process." @default.
- W2022178194 created "2016-06-24" @default.
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- W2022178194 date "2011-02-01" @default.
- W2022178194 modified "2023-10-16" @default.
- W2022178194 title "18F-FDG Uptake and Calcifications in the Thoracic Aorta on Positron Emission Tomography/Computed Tomography Examinations" @default.
- W2022178194 doi "https://doi.org/10.1097/rti.0b013e3181d9c9f9" @default.
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