Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022178426> ?p ?o ?g. }
- W2022178426 endingPage "725" @default.
- W2022178426 startingPage "717" @default.
- W2022178426 abstract "Alzheimer’s disease (AD) remains a major health problem, and accounts for 50 to 60% of all cases of dementia. The two histopathological hallmarks of AD are senile plaques, composed of the β-amyloid peptide (Aβ), and intraneuronal neurofibrillary tangles composed of abnormally hyperphosphorylated tau protein. Only a small proportion of AD is due to mutations in the genome of patients, the large majority of cases being of late onset and sporadic in origin. The relative contribution of genetics and environment to the sporadic cases is unclear, but they are accepted to be of multifactorial origin. This means that genetic and environmental factors can interact together to induce or accelerate the disease. Among environmental factors, studies suggest that hypothermia may contribute to the development and exacerbation AD. Here, we review the preclinical data involving hypothermia with tau and Aβ, as well as clinical evidence implicating hypothermia in the development of AD. Keywords: Alzheimer’s dementia, tau, beta Keywords: Alzheimer’s dementia, tau, beta-amyloid, phosphorylation, hypothermia, PP2A, phosphatases." @default.
- W2022178426 created "2016-06-24" @default.
- W2022178426 creator A5011526572 @default.
- W2022178426 creator A5036239397 @default.
- W2022178426 creator A5051156055 @default.
- W2022178426 creator A5063655189 @default.
- W2022178426 date "2010-12-01" @default.
- W2022178426 modified "2023-10-14" @default.
- W2022178426 title "Hypothermia and Alzheimers Disease Neuropathogenic Pathways" @default.
- W2022178426 cites W1457734077 @default.
- W2022178426 cites W1480786153 @default.
- W2022178426 cites W150987474 @default.
- W2022178426 cites W1511517753 @default.
- W2022178426 cites W1569576869 @default.
- W2022178426 cites W1574697207 @default.
- W2022178426 cites W157501186 @default.
- W2022178426 cites W1600169467 @default.
- W2022178426 cites W1600934558 @default.
- W2022178426 cites W1739965287 @default.
- W2022178426 cites W1845614074 @default.
- W2022178426 cites W1931200394 @default.
- W2022178426 cites W1944049145 @default.
- W2022178426 cites W1944078436 @default.
- W2022178426 cites W1954244449 @default.
- W2022178426 cites W1962351296 @default.
- W2022178426 cites W1963568158 @default.
- W2022178426 cites W1963791487 @default.
- W2022178426 cites W1966959566 @default.
- W2022178426 cites W1968937229 @default.
- W2022178426 cites W1969106223 @default.
- W2022178426 cites W1969170205 @default.
- W2022178426 cites W1969965994 @default.
- W2022178426 cites W1971165215 @default.
- W2022178426 cites W1973774127 @default.
- W2022178426 cites W1974469933 @default.
- W2022178426 cites W1975040221 @default.
- W2022178426 cites W1975596414 @default.
- W2022178426 cites W1976445933 @default.
- W2022178426 cites W1977560589 @default.
- W2022178426 cites W1977879318 @default.
- W2022178426 cites W1980768099 @default.
- W2022178426 cites W1982803266 @default.
- W2022178426 cites W1983856659 @default.
- W2022178426 cites W1984044273 @default.
- W2022178426 cites W1985256275 @default.
- W2022178426 cites W1985824402 @default.
- W2022178426 cites W1988818712 @default.
- W2022178426 cites W1991516886 @default.
- W2022178426 cites W1995562130 @default.
- W2022178426 cites W1996752129 @default.
- W2022178426 cites W2000251927 @default.
- W2022178426 cites W2001984402 @default.
- W2022178426 cites W2003275051 @default.
- W2022178426 cites W2005199015 @default.
- W2022178426 cites W2005379491 @default.
- W2022178426 cites W2007733484 @default.
- W2022178426 cites W2009647873 @default.
- W2022178426 cites W2010925911 @default.
- W2022178426 cites W2010973557 @default.
- W2022178426 cites W2011092266 @default.
- W2022178426 cites W2016543968 @default.
- W2022178426 cites W2016877136 @default.
- W2022178426 cites W2021312655 @default.
- W2022178426 cites W2022075010 @default.
- W2022178426 cites W2022614808 @default.
- W2022178426 cites W2023227738 @default.
- W2022178426 cites W2024977010 @default.
- W2022178426 cites W2025895354 @default.
- W2022178426 cites W2027376281 @default.
- W2022178426 cites W2027602632 @default.
- W2022178426 cites W2028489474 @default.
- W2022178426 cites W2031745631 @default.
- W2022178426 cites W2032112059 @default.
- W2022178426 cites W2036008741 @default.
- W2022178426 cites W2039270622 @default.
- W2022178426 cites W2039467481 @default.
- W2022178426 cites W2039468514 @default.
- W2022178426 cites W2041124411 @default.
- W2022178426 cites W2042262300 @default.
- W2022178426 cites W2043889745 @default.
- W2022178426 cites W2044669080 @default.
- W2022178426 cites W2046948369 @default.
- W2022178426 cites W2050209993 @default.
- W2022178426 cites W2053116497 @default.
- W2022178426 cites W2054619408 @default.
- W2022178426 cites W2057316984 @default.
- W2022178426 cites W2058570072 @default.
- W2022178426 cites W2058904679 @default.
- W2022178426 cites W2060431583 @default.
- W2022178426 cites W2061053746 @default.
- W2022178426 cites W2062914907 @default.
- W2022178426 cites W2063193894 @default.
- W2022178426 cites W2065718845 @default.
- W2022178426 cites W2065837685 @default.
- W2022178426 cites W2066232800 @default.
- W2022178426 cites W2066343710 @default.
- W2022178426 cites W2072226883 @default.
- W2022178426 cites W2075700581 @default.