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- W2022178663 abstract "SummaryIn cell transfer experiments C3H recipients, which had been immunosuppressed by cycloleucine, were capable of initiating a primary response to sheep erythrocytes if they were given macrophage-antigen mixtures frolm normal or from Cytoxantreated donors. Similarly prepared macrophages from cycloleucine-treated donors and crude cell suspensions derived from normal spleens were ineffective. If the recipients were immunosuppressed with Cytosan, the results were reversed, in that normal spleen cell-antigen mixtures stimulated antibody synthesis but normal macrophage-antigen mixtures did not. The data which were obtained with drug-treated and with Xirradiated recipients support the concept that antigen processing by the macrophage is necessary for initiating a primary type immune response. They also demonstrate the selective susceptibility of macrophages and spleen cells to immunosuppressive drugs." @default.
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- W2022178663 date "1969-10-01" @default.
- W2022178663 modified "2023-10-14" @default.
- W2022178663 title "Cell Transfer Studies in Immunosuppressed Mice: The Role of the Macrophage" @default.
- W2022178663 doi "https://doi.org/10.3181/00379727-132-34144" @default.
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