FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022179977> ?p ?o ?g. }

• W2022179977 endingPage "e32455" @default.
• W2022179977 startingPage "e32455" @default.
• W2022179977 abstract "The overrepresented approach (ORA) is the most widely-accepted method for functional analysis of microarray datasets. The ORA is computationally-efficient and robust; however, it suffers from the inability of comparing results from multiple gene lists particularly with time-course experiments or those involving multiple treatments. To overcome such limitation a novel method termed Dynamic Impact Approach (DIA) is proposed. The DIA provides an estimate of the biological impact of the experimental conditions and the direction of the impact. The impact is obtained by combining the proportion of differentially expressed genes (DEG) with the log2 mean fold change and mean -log P-value of genes associated with the biological term. The direction of the impact is calculated as the difference of the impact of up-regulated DEG and down-regulated DEG associated with the biological term. The DIA was validated using microarray data from a time-course experiment of bovine mammary gland across the lactation cycle. Several annotation databases were analyzed with DIA and compared to the same analysis performed by the ORA. The DIA highlighted that during lactation both BTA6 and BTA14 were the most impacted chromosomes; among Uniprot tissues those related with lactating mammary gland were the most positively-impacted; within KEGG pathways 'Galactose metabolism' and several metabolism categories related to lipid synthesis were among the most impacted and induced; within Gene Ontology lactose biosynthesis among Biological processes and Lactose synthase activity and Stearoyl-CoA 9-desaturase activity among Molecular processes were the most impacted and induced. With the exception of the terms 'Milk', 'Milk protein' and 'Mammary gland' among Uniprot tissues and SP_PIR_Keyword, the use of ORA failed to capture as significantly-enriched (i.e., biologically relevant) any term known to be associated with lactating mammary gland. Results indicate the DIA is a biologically-sound approach for analysis of time-course experiments. This tool represents an alternative to ORA for functional analysis." @default.
• W2022179977 created "2016-06-24" @default.
• W2022179977 creator A5009466330 @default.
• W2022179977 creator A5058590776 @default.
• W2022179977 creator A5062751234 @default.
• W2022179977 creator A5069092820 @default.
• W2022179977 creator A5078504589 @default.
• W2022179977 date "2012-03-16" @default.
• W2022179977 modified "2023-10-15" @default.
• W2022179977 title "A Novel Dynamic Impact Approach (DIA) for Functional Analysis of Time-Course Omics Studies: Validation Using the Bovine Mammary Transcriptome" @default.
• W2022179977 cites W1516084859 @default.
• W2022179977 cites W1828150019 @default.
• W2022179977 cites W1935910619 @default.
• W2022179977 cites W1964780208 @default.
• W2022179977 cites W1975693989 @default.
• W2022179977 cites W1980384488 @default.
• W2022179977 cites W1983635776 @default.
• W2022179977 cites W1993026959 @default.
• W2022179977 cites W1995920820 @default.
• W2022179977 cites W1998084411 @default.
• W2022179977 cites W2009657185 @default.
• W2022179977 cites W2024099760 @default.
• W2022179977 cites W2027584386 @default.
• W2022179977 cites W2034047925 @default.
• W2022179977 cites W2035360185 @default.
• W2022179977 cites W2067569885 @default.
• W2022179977 cites W2084763961 @default.
• W2022179977 cites W2097027766 @default.
• W2022179977 cites W2098381128 @default.
• W2022179977 cites W2099568121 @default.
• W2022179977 cites W2100474697 @default.
• W2022179977 cites W2101167680 @default.
• W2022179977 cites W2104382705 @default.
• W2022179977 cites W2125105410 @default.
• W2022179977 cites W2127072844 @default.
• W2022179977 cites W2133465414 @default.
• W2022179977 cites W2138075827 @default.
• W2022179977 cites W2141831395 @default.
• W2022179977 cites W2143351393 @default.
• W2022179977 cites W2146204746 @default.
• W2022179977 cites W2154425201 @default.
• W2022179977 cites W2154972152 @default.
• W2022179977 cites W2158217645 @default.
• W2022179977 cites W2164559559 @default.
• W2022179977 cites W2166992789 @default.
• W2022179977 cites W2169045355 @default.
• W2022179977 cites W2169866472 @default.
• W2022179977 cites W2187656845 @default.
• W2022179977 cites W2415841503 @default.
• W2022179977 cites W2490849176 @default.
• W2022179977 doi "https://doi.org/10.1371/journal.pone.0032455" @default.
• W2022179977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3306320" @default.
• W2022179977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22438877" @default.
• W2022179977 hasPublicationYear "2012" @default.
• W2022179977 type Work @default.
• W2022179977 sameAs 2022179977 @default.
• W2022179977 citedByCount "87" @default.
• W2022179977 countsByYear W20221799772012 @default.
• W2022179977 countsByYear W20221799772013 @default.
• W2022179977 countsByYear W20221799772014 @default.
• W2022179977 countsByYear W20221799772015 @default.
• W2022179977 countsByYear W20221799772016 @default.
• W2022179977 countsByYear W20221799772017 @default.
• W2022179977 countsByYear W20221799772018 @default.
• W2022179977 countsByYear W20221799772019 @default.
• W2022179977 countsByYear W20221799772020 @default.
• W2022179977 countsByYear W20221799772021 @default.
• W2022179977 countsByYear W20221799772022 @default.
• W2022179977 countsByYear W20221799772023 @default.
• W2022179977 crossrefType "journal-article" @default.
• W2022179977 hasAuthorship W2022179977A5009466330 @default.
• W2022179977 hasAuthorship W2022179977A5058590776 @default.
• W2022179977 hasAuthorship W2022179977A5062751234 @default.
• W2022179977 hasAuthorship W2022179977A5069092820 @default.
• W2022179977 hasAuthorship W2022179977A5078504589 @default.
• W2022179977 hasBestOaLocation W20221799771 @default.
• W2022179977 hasConcept C104317684 @default.
• W2022179977 hasConcept C121608353 @default.
• W2022179977 hasConcept C150194340 @default.
• W2022179977 hasConcept C152724338 @default.
• W2022179977 hasConcept C157585117 @default.
• W2022179977 hasConcept C162317418 @default.
• W2022179977 hasConcept C186836561 @default.
• W2022179977 hasConcept C202264299 @default.
• W2022179977 hasConcept C2776659692 @default.
• W2022179977 hasConcept C2778001805 @default.
• W2022179977 hasConcept C2779018089 @default.
• W2022179977 hasConcept C2779234561 @default.
• W2022179977 hasConcept C2987395477 @default.
• W2022179977 hasConcept C4733338 @default.
• W2022179977 hasConcept C530470458 @default.
• W2022179977 hasConcept C54355233 @default.
• W2022179977 hasConcept C55493867 @default.
• W2022179977 hasConcept C60644358 @default.
• W2022179977 hasConcept C70721500 @default.
• W2022179977 hasConcept C8415881 @default.
• W2022179977 hasConcept C86803240 @default.
• W2022179977 hasConcept C9927688 @default.

• next