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• W2022180752 abstract "hy did I get colon cancer?” The search for answers to this vexing question has led to the identification of an increasing number of genetic disorders that predispose to colorectal cancer. Although these syndromes in aggregate probably account for fewer than 5% of colorectal cancers, clinical recognition of these disorders is essential to assure that the best clinical recommendations are made for treatment of affected individuals. Recognition is also essential for understanding risks for second cancers — both gastrointestinal (GI) and non-GI cancers— in the patients as well as in their relatives. Diagnosis of a familial cancer predisposition syndrome yields a powerful tool in guiding clinical management aimed at early detection and prevention of cancers in such families. This article is written as a primer on the recognition and diagnosis of known hereditary syndromes that predispose individuals to colorectal cancers. Without recognition of these syndromes, patients are denied opportunities for receiving the best possible medical care. (Comprehensive discussion of the clinical management of each of these syndromes will not be provided, because this can be found elsewhere.) 1– 8 Although confirmation of a diagnosis of a hereditary cancer syndrome can sometimes be accomplished with genetic testing, this is not always feasible or desirable and is seldom the best place to start. Genetic testing is but one component of a more complex process often called genetic risk assessment. The net outcome of genetic risk assessment should be the development of a customized plan for cancer management for the patients and their at-risk relatives." @default.
• W2022180752 created "2016-06-24" @default.
• W2022180752 creator A5029739993 @default.
• W2022180752 date "2004-05-01" @default.
• W2022180752 modified "2023-09-23" @default.
• W2022180752 title "Recognition of genetic syndromes in families with suspected hereditary colon cancer syndromes" @default.
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• W2022180752 doi "https://doi.org/10.1016/s1542-3565(04)00120-x" @default.
• W2022180752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15118973" @default.
• W2022180752 hasPublicationYear "2004" @default.
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