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• W2022183936 endingPage "679" @default.
• W2022183936 startingPage "674" @default.
• W2022183936 abstract "The aim of this study was to find out the profile of cellular glutathione (GSH) and GSH S-transferase (GST) in hepatocytes differentiated from adult mesenchymal stem cells (MSC). For this purpose, we have derived functionally active hepatocyte-like cells from normal human multipotent adult MSC. Then the differentiated cells were characterized by specific hepatic markers. The cellular GSH and GST catalytic activity toward 1-chloro-2,4-dinitrobenzene (CDNB) were determined in hepatocyte-like cells differentiated from MSC compared with undifferentiated MSC. Reverse transcription polymerase chain reaction (RT-PCR) and immunoblotting techniques were used to study GST-P1-1 and GST-A1-1 expression in differentiated and undifferentiated cells. The results showed that there is more than threefold increase in GST catalytic activity in hepatocytes recovered by day 14 of differentiation. GST-P1-1 mRNA expression was detected in both differentiated hepatocyte-like cells and their undifferentiated progenitors. Under similar conditions, only differentiated hepatocyte-like cells expressed GST-A1-1 mRNA. These results were further confirmed by showing that the undifferentiated cells expressed both GST-A and GST-P proteins. Unlike GST, the level of cellular GSH was declined (approximately 20%) in hepatocytes derived from MSC as compared to that of undifferentiated cells. These data may suggest that hepatogenic differentiation of human bone marrow MSC is accompanied with the regulation of factors participating in GSH conjugation pathway." @default.
• W2022183936 created "2016-06-24" @default.
• W2022183936 creator A5020198157 @default.
• W2022183936 creator A5024971399 @default.
• W2022183936 creator A5058045726 @default.
• W2022183936 creator A5074024316 @default.
• W2022183936 date "2009-06-01" @default.
• W2022183936 modified "2023-10-02" @default.
• W2022183936 title "Differential expression of glutathione S-transferases P1-1 and A1-1 at protein and mRNA levels in hepatocytes derived from human bone marrow mesenchymal stem cells" @default.
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• W2022183936 doi "https://doi.org/10.1016/j.tiv.2009.01.018" @default.
• W2022183936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19490842" @default.
• W2022183936 hasPublicationYear "2009" @default.
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