Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022184416> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2022184416 endingPage "154" @default.
- W2022184416 startingPage "147" @default.
- W2022184416 abstract "To determine whether the rat homolog of intercellular adhesion molecule 1 (ICAM-1) plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) we examined the effect of anti-ICAM-1 mAb, 1A29, on both active and passive EAE. We also examined its effect on a model of cytokine-induced inflammation in the central nervous system. Treatment of recipients of EAE effector cells with anti-ICAM-1 had no inhibitory activity, and in fact at high doses, treatment enhanced disease as evidenced by an earlier onset of symptoms. Treatment of active EAE with anti-ICAM-1 beginning on the day of sensitization did protect a proportion of animals from development of disease as well as reduce the severity of clinical signs in those which developed symptoms. Lymphocytes from both the draining lymph nodes and spleens of myelin basic protein (MBP)-immunized rats treated with anti-ICAM-1 failed to proliferate in response to MBP in vitro, suggesting that the antibody had prevented the animals from becoming sensitized to the antigen. Microinjection of tumor necrosis factor (TNF)-alpha into the spinal cords of rats led to the expression of ICAM-1 on vascular endothelium, and to the accumulation of leukocytes at sites of injection. The peak expression of ICAM-1 by endothelium and the peak accumulation of leukocytes following TNF alpha injection were not positively correlated. Furthermore, treatment of TNF alpha injected rats with anti-ICAM-1 did not inhibit the accumulation of leukocytes at the site of cytokine injection.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2022184416 created "2016-06-24" @default.
- W2022184416 creator A5014353955 @default.
- W2022184416 creator A5015449816 @default.
- W2022184416 creator A5032286218 @default.
- W2022184416 creator A5036006439 @default.
- W2022184416 date "1993-06-01" @default.
- W2022184416 modified "2023-09-26" @default.
- W2022184416 title "ICAM-1-dependent pathway is not critically involved in the inflammatory process of autoimmune encephalomyelitis or in cytokine-induced inflammation of the central nervous system" @default.
- W2022184416 cites W1514064771 @default.
- W2022184416 cites W1977461031 @default.
- W2022184416 cites W1996255823 @default.
- W2022184416 cites W1996266000 @default.
- W2022184416 cites W2007027096 @default.
- W2022184416 cites W2023313730 @default.
- W2022184416 cites W2032371793 @default.
- W2022184416 cites W2038846275 @default.
- W2022184416 cites W2056335777 @default.
- W2022184416 cites W2075781827 @default.
- W2022184416 cites W2083464618 @default.
- W2022184416 cites W2088073016 @default.
- W2022184416 cites W2093260672 @default.
- W2022184416 cites W2102364802 @default.
- W2022184416 cites W2134771885 @default.
- W2022184416 cites W2157279574 @default.
- W2022184416 cites W2328681916 @default.
- W2022184416 doi "https://doi.org/10.1016/0165-5728(93)90175-x" @default.
- W2022184416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7687251" @default.
- W2022184416 hasPublicationYear "1993" @default.
- W2022184416 type Work @default.
- W2022184416 sameAs 2022184416 @default.
- W2022184416 citedByCount "73" @default.
- W2022184416 countsByYear W20221844162014 @default.
- W2022184416 countsByYear W20221844162015 @default.
- W2022184416 countsByYear W20221844162016 @default.
- W2022184416 countsByYear W20221844162021 @default.
- W2022184416 crossrefType "journal-article" @default.
- W2022184416 hasAuthorship W2022184416A5014353955 @default.
- W2022184416 hasAuthorship W2022184416A5015449816 @default.
- W2022184416 hasAuthorship W2022184416A5032286218 @default.
- W2022184416 hasAuthorship W2022184416A5036006439 @default.
- W2022184416 hasConcept C126322002 @default.
- W2022184416 hasConcept C16224149 @default.
- W2022184416 hasConcept C17991360 @default.
- W2022184416 hasConcept C185946421 @default.
- W2022184416 hasConcept C203014093 @default.
- W2022184416 hasConcept C2776914184 @default.
- W2022184416 hasConcept C2777899865 @default.
- W2022184416 hasConcept C2778486448 @default.
- W2022184416 hasConcept C2778609137 @default.
- W2022184416 hasConcept C2778690821 @default.
- W2022184416 hasConcept C2780640218 @default.
- W2022184416 hasConcept C2780876595 @default.
- W2022184416 hasConcept C2780942790 @default.
- W2022184416 hasConcept C529278444 @default.
- W2022184416 hasConcept C71924100 @default.
- W2022184416 hasConceptScore W2022184416C126322002 @default.
- W2022184416 hasConceptScore W2022184416C16224149 @default.
- W2022184416 hasConceptScore W2022184416C17991360 @default.
- W2022184416 hasConceptScore W2022184416C185946421 @default.
- W2022184416 hasConceptScore W2022184416C203014093 @default.
- W2022184416 hasConceptScore W2022184416C2776914184 @default.
- W2022184416 hasConceptScore W2022184416C2777899865 @default.
- W2022184416 hasConceptScore W2022184416C2778486448 @default.
- W2022184416 hasConceptScore W2022184416C2778609137 @default.
- W2022184416 hasConceptScore W2022184416C2778690821 @default.
- W2022184416 hasConceptScore W2022184416C2780640218 @default.
- W2022184416 hasConceptScore W2022184416C2780876595 @default.
- W2022184416 hasConceptScore W2022184416C2780942790 @default.
- W2022184416 hasConceptScore W2022184416C529278444 @default.
- W2022184416 hasConceptScore W2022184416C71924100 @default.
- W2022184416 hasIssue "1-2" @default.
- W2022184416 hasLocation W20221844161 @default.
- W2022184416 hasLocation W20221844162 @default.
- W2022184416 hasOpenAccess W2022184416 @default.
- W2022184416 hasPrimaryLocation W20221844161 @default.
- W2022184416 hasRelatedWork W1603006134 @default.
- W2022184416 hasRelatedWork W1632082553 @default.
- W2022184416 hasRelatedWork W1992761883 @default.
- W2022184416 hasRelatedWork W2015271395 @default.
- W2022184416 hasRelatedWork W2017885089 @default.
- W2022184416 hasRelatedWork W2166551342 @default.
- W2022184416 hasRelatedWork W2398591771 @default.
- W2022184416 hasRelatedWork W2415883113 @default.
- W2022184416 hasRelatedWork W2588692501 @default.
- W2022184416 hasRelatedWork W82344848 @default.
- W2022184416 hasVolume "45" @default.
- W2022184416 isParatext "false" @default.
- W2022184416 isRetracted "false" @default.
- W2022184416 magId "2022184416" @default.
- W2022184416 workType "article" @default.