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- W2022185246 abstract "Abstract: : Guinea‐pig synaptosomes possess two functional pools of 4‐aminobutyrate (GABA). One is rapidly labelled by added [ I4 C]GABA, is steadily released in a Ca 2+ ‐independent manner when the Na + electrochemical potential across the plasma membrane is collapsed, and is depleted by the GABA analogue 2,4‐diaminobutyrate (DABA), all of which is consistent with a cytosolic location. A second, noncytosolic compartment only slowly equilibrates with exogenous [ 14 C]GABA, is not depleted by DABA, but can release 350 pmol of endogenous GABA/mg of protein (8% of the total intrasynaptosomal GABA) within 15 s of depolarization in the presence of Ca 2+ . Ca 2+ ‐independent release occurs by thermodynamic reversal of the plasma membrane uptake pathway following artifactually prolonged depolarization, whereas Ca 2+ ‐dependent release is consistent with physiological exocytosis from vesicular stores." @default.
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- W2022185246 date "1987-07-01" @default.
- W2022185246 modified "2023-10-14" @default.
- W2022185246 title "4‐Aminobutyrate Can Be Released Exocytotically from Guinea‐Pig Cerebral Cortical Synaptosomes" @default.
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- W2022185246 doi "https://doi.org/10.1111/j.1471-4159.1987.tb03424.x" @default.
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