Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022186661> ?p ?o ?g. }
- W2022186661 endingPage "777" @default.
- W2022186661 startingPage "761" @default.
- W2022186661 abstract "Levodopa remains the most potent drug to treat motor symptoms in Parkinson’s disease (PD); however, motor fluctuations and levodopa-induced dyskinesia that occur with long-term use restrict some of its therapeutic value. Despite these limitations, the medical treatment of PD strives for continuous relief of symptoms using different strategies throughout the course of the illness: increasing the half-life of levodopa, using ‘levodopa-sparing agents’ and adding non-dopaminergic drugs. New options to ‘improve’ delivery of levodopa are under investigation, including long-acting levodopa, nasal inhalation and continuous subcutaneous or intrajejunal administration of levodopa. Long-acting dopamine agonists were recently developed and are undergoing further comparative studies to investigate potential superiority over the immediate-release formulations. Non-dopaminergic drugs acting on adenosine receptors, cholinergic, adrenergic, serotoninergic and glutamatergic pathways are newly developed and many are being evaluated in Phase II and Phase III trials. This article focuses on promising novel therapeutic approaches for the management of PD motor symptoms and motor complications. We will provide an update since 2011 on new formulations of current drugs, new drugs with promising results in Phase II and Phase III clinical trials, old drugs with new possibilities and some new potential strategies that are currently in Phase I and II of development (study start date may precede 2011 but are included as study is still ongoing or full data have not yet been published). Negative Phase II and Phase III clinical trials published since 2011 will also be briefly mentioned." @default.
- W2022186661 created "2016-06-24" @default.
- W2022186661 creator A5048688457 @default.
- W2022186661 creator A5069387790 @default.
- W2022186661 date "2014-10-16" @default.
- W2022186661 modified "2023-09-24" @default.
- W2022186661 title "New treatments for the motor symptoms of Parkinson’s disease" @default.
- W2022186661 cites W1491076928 @default.
- W2022186661 cites W1493115321 @default.
- W2022186661 cites W1547633323 @default.
- W2022186661 cites W1577054006 @default.
- W2022186661 cites W1631523450 @default.
- W2022186661 cites W1900959796 @default.
- W2022186661 cites W1964287067 @default.
- W2022186661 cites W1968407662 @default.
- W2022186661 cites W1969903608 @default.
- W2022186661 cites W1978103789 @default.
- W2022186661 cites W1978647688 @default.
- W2022186661 cites W1981123646 @default.
- W2022186661 cites W1981292076 @default.
- W2022186661 cites W1981806544 @default.
- W2022186661 cites W1982397024 @default.
- W2022186661 cites W1985128254 @default.
- W2022186661 cites W1985560386 @default.
- W2022186661 cites W1992021084 @default.
- W2022186661 cites W1996219683 @default.
- W2022186661 cites W1999335544 @default.
- W2022186661 cites W2004091634 @default.
- W2022186661 cites W2005167173 @default.
- W2022186661 cites W2008560062 @default.
- W2022186661 cites W2010485061 @default.
- W2022186661 cites W2015594730 @default.
- W2022186661 cites W2017424741 @default.
- W2022186661 cites W2021828427 @default.
- W2022186661 cites W2022209842 @default.
- W2022186661 cites W2022712158 @default.
- W2022186661 cites W2024309041 @default.
- W2022186661 cites W2024469991 @default.
- W2022186661 cites W2034588648 @default.
- W2022186661 cites W2034909646 @default.
- W2022186661 cites W2037673105 @default.
- W2022186661 cites W2038505488 @default.
- W2022186661 cites W2041840461 @default.
- W2022186661 cites W2042457707 @default.
- W2022186661 cites W2044463545 @default.
- W2022186661 cites W2049948842 @default.
- W2022186661 cites W2052119205 @default.
- W2022186661 cites W2059945987 @default.
- W2022186661 cites W2065085230 @default.
- W2022186661 cites W2065268878 @default.
- W2022186661 cites W2068416041 @default.
- W2022186661 cites W2070013653 @default.
- W2022186661 cites W2070912312 @default.
- W2022186661 cites W2073196506 @default.
- W2022186661 cites W2073508271 @default.
- W2022186661 cites W2075621586 @default.
- W2022186661 cites W2081525752 @default.
- W2022186661 cites W2085013861 @default.
- W2022186661 cites W2093058270 @default.
- W2022186661 cites W2097863680 @default.
- W2022186661 cites W2107758668 @default.
- W2022186661 cites W2108069241 @default.
- W2022186661 cites W2108299953 @default.
- W2022186661 cites W2109364412 @default.
- W2022186661 cites W2109832016 @default.
- W2022186661 cites W2111597060 @default.
- W2022186661 cites W2112467057 @default.
- W2022186661 cites W2113568942 @default.
- W2022186661 cites W2114682795 @default.
- W2022186661 cites W2116639272 @default.
- W2022186661 cites W2120939032 @default.
- W2022186661 cites W2124065800 @default.
- W2022186661 cites W2129848379 @default.
- W2022186661 cites W2139909171 @default.
- W2022186661 cites W2146173262 @default.
- W2022186661 cites W2151970539 @default.
- W2022186661 cites W2166618774 @default.
- W2022186661 cites W3161511225 @default.
- W2022186661 cites W39072687 @default.
- W2022186661 cites W4211223857 @default.
- W2022186661 cites W4298856930 @default.
- W2022186661 doi "https://doi.org/10.1586/17512433.2014.966812" @default.
- W2022186661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25318835" @default.
- W2022186661 hasPublicationYear "2014" @default.
- W2022186661 type Work @default.
- W2022186661 sameAs 2022186661 @default.
- W2022186661 citedByCount "27" @default.
- W2022186661 countsByYear W20221866612015 @default.
- W2022186661 countsByYear W20221866612016 @default.
- W2022186661 countsByYear W20221866612017 @default.
- W2022186661 countsByYear W20221866612018 @default.
- W2022186661 countsByYear W20221866612019 @default.
- W2022186661 countsByYear W20221866612020 @default.
- W2022186661 countsByYear W20221866612021 @default.
- W2022186661 countsByYear W20221866612022 @default.
- W2022186661 countsByYear W20221866612023 @default.
- W2022186661 crossrefType "journal-article" @default.
- W2022186661 hasAuthorship W2022186661A5048688457 @default.