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- W2022186892 abstract "We describe the shortest prion protein allele known to date. Surprisingly, it is found as a polymorphism exactly in a species (prosimian lemurs) which seems highly susceptible to oral infection with BSE-derived prions. The truncation of the prion protein we found raises several questions. First, is the truncated octarepeat structure we describe, consisting of two octarepeats, still functional in copper binding? A second question is whether this truncation is related to the remarkable oral infectibility of lemurs with BSE-derived prions. And finally, one could argue that this genotype alone might favour development of a prion disease, even in the absence of exogenous infection." @default.
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- W2022186892 date "2000-01-21" @default.
- W2022186892 modified "2023-09-27" @default.
- W2022186892 title "Shortest Known Prion Protein Allele in Highly BSE-Susceptible Lemurs" @default.
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- W2022186892 doi "https://doi.org/10.1515/bc.2000.067" @default.
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